Preschool- and School-Age Irritability Predict Reward-Related Brain Function.
<bold>Objective: </bold>Although chronic irritability in childhood is prevalent, impairing, and predictive of later maladjustment, its pathophysiology is largely unknown. Deficits in reward processing are hypothesized to play a role in irritability. The current study aimed to identify how the develo...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 57; no. 6; pp. 407 - 408 |
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| Autores principales: | , , , , , , |
| Formato: | journal article |
| Publicado: |
Elsevier B.V.
Jun2018
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=129908463&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 129908463 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: Jun2018 vid: 57 iid: 6 pid: 467 pub: Elsevier B.V. artinfo: ui: 129908463 10.1016/j.jaac.2018.03.012 ppf: 407 ppct: 1 formats: tig: atl: Preschool- and School-Age Irritability Predict Reward-Related Brain Function. aug: au: Dougherty, Lea R. Schwartz, Karen T.G. Kryza-Lacombe, Maria Weisberg, Jill Spechler, Philip A. Lee Wiggins, Jillian Wiggins, Jillian Lee affil: University of Maryland, College Park, MD San Diego State University, CA, and University of California, San Diego Joint Doctoral Program in Clinical Psychology su: Brain function localization Brain imaging Brain mapping Neural circuitry Irritability (Psychology) sug: subj: Brain function localization Brain imaging Brain mapping Neural circuitry Irritability (Psychology) keyword: connectivity fMRI irritability reward connectivity fMRI irritability reward ab: <bold>Objective: </bold>Although chronic irritability in childhood is prevalent, impairing, and predictive of later maladjustment, its pathophysiology is largely unknown. Deficits in reward processing are hypothesized to play a role in irritability. The current study aimed to identify how the developmental timing of irritability during preschool- and school-age relates to reward-related brain function during school-age.<bold>Method: </bold>Children's irritability was assessed during the preschool period (wave 1; ages 3.0-5.9 years) and 3 years later (wave 2; ages 5.9-9.6 years) using a clinical interview. At wave 2, children (N = 46; 28 female and 18 male) performed a monetary incentive delay task in which they received rewards, if they successfully hit a target, or no reward regardless of performance, during functional magnetic resonance imaging.<bold>Results: </bold>Children with more versus less severe preschool irritability, controlling for concurrent irritability, exhibited altered reward-related connectivity: right amygdala with insula and inferior parietal lobe as well as left ventral striatum with lingual gyrus, postcentral gyrus, superior parietal lobe, and culmen. Children with more versus less severe concurrent irritability, controlling for preschool irritability, exhibited a similar pattern of altered connectivity between left and right amygdalae and superior frontal gyrus and between left ventral striatum and precuneus and culmen. Neural differences associated with irritability were most evident between reward and no-reward conditions when participants missed the target.<bold>Conclusion: </bold>Preschool-age irritability and concurrent irritability were uniquely associated with aberrant patterns of reward-related connectivity, highlighting the importance of developmental timing of irritability for brain function. pubtype: Academic Journal doctype: journal article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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