مقايسه ي ميزان ريشه كني هليكوباكتر پيلوري با چهار رژيم درماني چهار دارويي در بيماران دچار سوءهاضمه
Background and Objective: An optimal regimen for treatment of Helicobacter pylori should have high efficacy, tolerable side effects, easy administration and should be economical. Intensive efforts are being made to identify such an optimal regimen, but there are many obstacles hindering the achievem...
| Publicado en: | Journal of Zanjan University of Medical Sciences & Health Services Vol. 21; no. 86; pp. 1 - 12 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129911769&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129911769 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16069366 BA35 jtl: Journal of Zanjan University of Medical Sciences & Health Services issn: 16069366 maglogo: N pubinfo: dt: 2013 vid: 21 iid: 86 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 129911769 129911769 129911769 129911769 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: مقايسه ي ميزان ريشه كني هليكوباكتر پيلوري با چهار رژيم درماني چهار دارويي در بيماران دچار سوءهاضمه aug: au: فتاحي, ابراهيم صومي, محمد حسين غمخوار, عليرضا قويدل, علي فخرجو, اشرف فتاحي, شيرين نقاشي, شهناز affil: متخصص داخلي، استاد مركز تحقيقات بيماري هاي گوارش و كبد، دانشگاه علوم پزشكي تبريز sug: subj: Helicobacter Infections Drug Therapy Antiinfective Agents Therapeutic Use Antiinfective Agents Administration and Dosage Drug Combinations Dyspepsia Randomized Controlled Trials Human Urease Blood Random Assignment Omeprazole Therapeutic Use Amoxicillin Therapeutic Use Bismuth Therapeutic Use Clarithromycin Therapeutic Use Tetracycline Therapeutic Use Metronidazole Therapeutic Use Nitrofurans Therapeutic Use Treatment Duration Abdominal Pain Chemically Induced Vomiting Chemically Induced Adverse Drug Event Medication Compliance Treatment Outcomes ab: Background and Objective: An optimal regimen for treatment of Helicobacter pylori should have high efficacy, tolerable side effects, easy administration and should be economical. Intensive efforts are being made to identify such an optimal regimen, but there are many obstacles hindering the achievement of this goal. This study aimed at comparing the rate of HP eradication by examining quadruple regimens in dyspeptic patients. Materials and Methods: In this open-label randomized clinical trial, 270 patients with positive Urease test were randomly assigned into four groups to receive one of the following treatment protocols. ( group A: omeprazole+ amoxicillin+ bismuth subcitrate+clarithromycin for 2 weeks (73 patients), group B: omeprazole+tetracycline+bismuth subcitrate+metronidazole for 2 weeks (46 patients), group C: omeprazole+amoxicillin+bismuth subcitrate+furazolidone for 2 weeks (64 patients), groupD: omeprazole+amoxicillin+bismuth subcitrate+furazolidone/metronidazole interchangeably each one for one week (87 patients). Six weeks after the treatment, the compliance, eradication and complication rates were evaluated in each group. Results: Helicobacter pylori eradication rates were, 96.3%, 87%, 79.7%, and 79.3 % in groups A, B, C and D respectively (p=0.506). The overall complication rate was 37%, 63%, 32.8% and 28.7% in groups A, B, C and D respectively. This rate was significantly higher in group B than other groups (p=0.01). The compliance rate was “complete”, ‘good” or “poor”. Accordingly the compliance rate in group A was 83.6%, 11% and 5.5%, in group B, 87%, 6.5% and 6.5%, in group C. 90.6%, 4.7% and 4.7%, and in group D 86.2%, 11.5% and 2.3%, respectively (p=0.683). Abdominal pain and vomiting was significantly more frequent in groups B and C compared to the other groups. The other complications were not significantly different in the groups. Conclusion: The rate of compliance and HP eradication was similar in quadruple regimens; however, due to difference in the rate of complications, regimens of groups A or D are recommended. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: Persian refInfo: holdings: @attributes: islocal: N |
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