Cardiorespiratory fitness and adiposity in breast cancer survivors: is meeting current physical activity recommendations really enough?

Purpose: Breast cancer (BC) survivors are becoming increasingly predisposed to cardiovascular disease (CVD) mortality. Low cardiorespiratory fitness and physical activity (PA) levels, as well as high values of adiposity indices, contribute to CVD risk. We evaluated adiposity, cardiorespiratory profi...

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Published in:Supportive Care in Cancer Vol. 26; no. 7; pp. 2293 - 2302
Main Authors: Santos-Lozano, Alejandro, Ramos, Javier, Alvarez-Bustos, Alejandro, Cantos, Blanca, Alejo, Lidia B., Pagola, Itziar, Soria, Ana, Maximiano, Constanza, Fiuza-Luces, Carmen, Soares-Miranda, Luisa, Lucia, Alejandro, Ruiz-Casado, Ana
Format: research tables/charts Journal Article
Published: Springer Nature Jul2018
Online Access:View this record in EBSCOhost
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      dt: Jul2018
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      pub: Springer Nature
      place: New York, New York
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        atl: Cardiorespiratory fitness and adiposity in breast cancer survivors: is meeting current physical activity recommendations really enough?
      aug:
        au:
          Santos-Lozano, Alejandro
          Ramos, Javier
          Alvarez-Bustos, Alejandro
          Cantos, Blanca
          Alejo, Lidia B.
          Pagola, Itziar
          Soria, Ana
          Maximiano, Constanza
          Fiuza-Luces, Carmen
          Soares-Miranda, Luisa
          Lucia, Alejandro
          Ruiz-Casado, Ana
        affil: Research Institute of Hospital 12 de Octubre (``i+12''), Madrid, Spain
      sug:
        subj:
          Exercise
          Breast Neoplasms Physiopathology
          Adipose Tissue Distribution Physiology
          Male
          Female
          Middle Age
          Funding Source
          Middle Aged: 45-64 years
          Male
          Female
      ab: Purpose: Breast cancer (BC) survivors are becoming increasingly predisposed to cardiovascular disease (CVD) mortality. Low cardiorespiratory fitness and physical activity (PA) levels, as well as high values of adiposity indices, contribute to CVD risk. We evaluated adiposity, cardiorespiratory profile, and PA levels in two independent cohorts of BC survivors.Methods: Data were collected from two groups (99% women) from different areas of Madrid (Spain): group 1, n = 110, age 51.4 ± 9.7 years, median time from diagnosis 365 days (95% confidence interval [CI], 354-401), and group 2, n = 93, age 54.7 ± 8.9 years, 1714 days (95% CI, 1502-1938). We estimated peak oxygen uptake (VO2peak) and measured body mass index (BMI), waist circumference (WC), waist-to-hip index, and accelerometry-determined PA.Results: Both groups had values of BMI in the overweight range (25.3 ± 4.3 and 27.1 ± 5.1 kg/m2, p = 0.003). Estimated VO2peak levels were lower in group 2 than in group 1 (28.1 ± 9.1 and 23.7 ± 8.8 ml/kg/min, p < 0.001), although levels in both groups were low. Yet, the majority of participants in both groups (81 and 88%, p = 0.234) met international PA recommendations (235 ± 196 and 351 ± 173 min/week of moderate-vigorous PA, p < 0.001). Both groups had very low levels of vigorous PA. These results were essentially independent of type of treatment (anthracycline/radiotherapy).Conclusions: We found a poor cardiorespiratory profile in two independent BC cohorts that differed in median time from diagnosis (as well in socioeconomic status), supporting the notion that implementation of PA (possibly focusing on vigorous PA) and dietary intervention is urgently needed in this patient population.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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