Diffusion tensor imaging determines three-dimensional architecture of human cervix: a cross-sectional study.
Objective: To determine the microarchitecture of the cervix using high-resolution diffusion tensor (DT) magnetic resonance imaging (MRI).Design: Cross-sectional study.Setting: Leeds, UK.Sample: Women undergoing hysterectomy for benign pathology.Methods: Ex-vivo DT-MRI measurements were obtained usin...
| Publicado en: | BJOG: An International Journal of Obstetrics & Gynaecology Vol. 125; no. 7; pp. 812 - 819 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129934654&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129934654 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14700328 KJ6 jtl: BJOG: An International Journal of Obstetrics & Gynaecology issn: 14700328 maglogo: Y pubinfo: dt: Jun2018 vid: 125 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 129934654 129934654 NLM29226548 129934654 10.1111/1471-0528.15002 NLM29226548 129934654 ppf: 812 ppct: 7 formats: tig: atl: Diffusion tensor imaging determines three-dimensional architecture of human cervix: a cross-sectional study. aug: au: Nott, J. P. Pervolaraki, E. Benson, A. P. Bonney, E. A. Pickering, J. D. Wilkinson, N. Simpson, N. A. B. Simpson, Nab affil: Division of Women's and Children's Health, University of Leeds, Leeds, UK sug: subj: Magnetic Resonance Imaging Methods Cervix Imaging, Three-Dimensional Methods Female Adult Cervix Pathology Hysterectomy Cross Sectional Studies Adult: 19-44 years Female ab: Objective: To determine the microarchitecture of the cervix using high-resolution diffusion tensor (DT) magnetic resonance imaging (MRI).Design: Cross-sectional study.Setting: Leeds, UK.Sample: Women undergoing hysterectomy for benign pathology.Methods: Ex-vivo DT-MRI measurements were obtained using a 9.4-T Bruker nuclear magnetic resonance (NMR) spectrometer on seven fixed human cervices obtained at hysterectomy. A deterministic fibre-tracking algorithm was used to indirectly visualise underlying fibre organisation. Inter-regional differences in tissue structure were sought using quantitative measurements of diffusion.Main Outcome Measure: The identification of an occlusive structure in the region corresponding to the internal cervical os.Results: Fibre tracking demonstrated two regions: an outer circular and inner longitudinal layer. The total circumferential tract volume (TV) was greatest in the proximal region of the cervix (TV: proximal, 271 ± 198 mm3 ; middle, 186 ± 119 mm3 ; distal, 38 ± 36 mm3 ). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements were significantly different between regions in all samples (P < 0.0005), indicating greater tract density and organisation towards the internal os.Conclusion: Fibre tracking infers a system of dense, well-defined, encircling fibres in the proximal region of the cervix, corresponding to the location of the internal os. These findings may provide evidence of specific anatomic microarchitecture within the cervix able to resist intrauterine forces associated with pregnancy.Tweetable Abstract: Diffusion-tensor MRI derived tractography identified well-defined encircling fibres at the internal os. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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