Subclinical changes in MRI-determined right ventricular volumes and function in subjects with prediabetes and diabetes.
Objectives: The aim of this study was to assess subclinical changes in right ventricular volumes and function in subjects with prediabetes and diabetes and controls without a history of cardiovascular disease.Methods: Data from 400 participants in the KORA FF4 study without self-reported cardiovascu...
| Publicado en: | European Radiology Vol. 28; no. 7; pp. 3105 - 3114 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129951929&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129951929 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2018 vid: 28 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129951929 129951929 NLM29423576 10.1007/s00330-017-5185-1 NLM29423576 129951929 ppf: 3105 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Subclinical changes in MRI-determined right ventricular volumes and function in subjects with prediabetes and diabetes. aug: au: Patscheider, Hannah Lorbeer, Roberto Auweter, Sigrid Schafnitzel, Anina Bayerl, Christian Curta, Adrian Rathmann, Wolfgang Heier, Margit Meisinger, Christa Peters, Annette Bamberg, Fabian Hetterich, Holger affil: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Marchioninistr. 15, 81377, Munich, Germany sug: subj: Ventricular Dysfunction, Right Diabetes Mellitus Linear Regression Prediabetic State Physiopathology Aged Magnetic Resonance Imaging Methods Ventricular Function, Right Physiology Case Control Studies Middle Age Ventricular Dysfunction, Right Physiopathology Female Male Adult Prediabetic State Diabetes Mellitus Physiopathology Heart Ventricle Physiopathology Stroke Volume Physiology Short Portable Mental Status Questionnaire Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objectives: The aim of this study was to assess subclinical changes in right ventricular volumes and function in subjects with prediabetes and diabetes and controls without a history of cardiovascular disease.Methods: Data from 400 participants in the KORA FF4 study without self-reported cardiovascular disease who underwent 3-T whole-body MRI were obtained. The right ventricle was evaluated using the short axis and a four-chamber view. Diabetes was defined according to WHO criteria. Associations between glucose tolerance and right ventricular parameters were assessed using multivariable adjusted linear regression models.Results: Data from 337 participants were available for analysis. Of these, 43 (13%) had diabetes, 87 (26%) had prediabetes, and 207 (61%) were normoglycaemic controls. There was a stepwise decrease in right ventricular volumes in men with prediabetes and diabetes in comparison with controls, including right ventricular end-diastolic volume (β = -20.4 and β = -25.6, respectively; p ≤ 0.005), right ventricular end-systolic volume (β = -12.3 and β = -12.7, respectively; p ≤ 0.037) and right ventricular stroke volume (β = -8.1 and β = -13.1, respectively, p ≤ 0.016). We did not observe any association between prediabetes or diabetes and right ventricular volumes in women or between prediabetes or diabetes and right ventricular ejection fraction in men and women.Conclusions: This study points towards early subclinical changes in right ventricular volumes in men with diabetes and prediabetes.Key Points: • MRI was used to detect subclinical changes in right ventricular parameters. • Diabetes mellitus is associated with right ventricular dysfunction. • Impairment of right ventricular volumes seems to occur predominantly in men. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|