Staging liver fibrosis with DWI: is there an added value for diffusion kurtosis imaging?
Objectives: To assess liver fibrosis in patients with chronic liver disease using diffusion kurtosis imaging (DKI) in comparison with conventional diffusion-weighted imaging, with histology as reference standard.Methods: This prospective study included 81 patients and DKI with b-values of 0, 200, 50...
| Publicado en: | European Radiology Vol. 28; no. 7; pp. 3041 - 3050 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129951938&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129951938 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2018 vid: 28 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129951938 129951938 NLM29383522 10.1007/s00330-017-5245-6 NLM29383522 129951938 ppf: 3041 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Staging liver fibrosis with DWI: is there an added value for diffusion kurtosis imaging? aug: au: Yang, Li Rao, Shengxiang Wang, Wentao Chen, Caizhong Ding, Ying Yang, Chun Grimm, Robert Yan, Xu Fu, Caixia Zeng, Mengsu affil: Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China sug: subj: Magnetic Resonance Imaging Methods Liver Cirrhosis Pilot Studies Prospective Studies Image Interpretation, Computer Assisted Methods Observer Bias Severity of Illness Indices Female Adult Sensitivity and Specificity Aged Male Liver Cirrhosis Pathology Middle Age Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To assess liver fibrosis in patients with chronic liver disease using diffusion kurtosis imaging (DKI) in comparison with conventional diffusion-weighted imaging, with histology as reference standard.Methods: This prospective study included 81 patients and DKI with b-values of 0, 200, 500, 1,000, 1,500, 2,000 s/mm2 were performed. Mean diffusivity (MD), mean kurtosis (MK) and apparent diffusion coefficient (ADC) maps were calculated. The diagnostic efficacy of MD, MK and ADC for predicting stage 2 fibrosis or greater, and stage 3 fibrosis or greater were compared.Results: The MD (rho=-0.491, p<0.001), MK (rho=0.537, p<0.001) and ADC (rho=-0.496, p<0.001) correlated significantly with fibrosis stages, and ADC exhibited a strong negative correlation with MK (rho=-0.968; p<0.001) and a moderate association with MD (rho=0.601, p<0.001). Areas under the curves (AUCs) for predicting stage 2 fibrosis or greater were not significantly different (p>0.05) between MK (0.809) and ADC (0.797) as well as between MD (0.715) and ADC. AUCs were also similar for MD (0.710), MK (0.768) and ADC (0.747) for predicting stage 3 fibrosis or greater.Conclusion: Although DKI is feasible for predicting liver fibrosis in patients with chronic liver disease, MD and MK offer similar diagnostic performance to ADC values.Key Points: • Diffusion kurtosis imaging is feasible for staging liver fibrosis. • Diffusion kurtosis and monoexponential model are highly correlated. • The kurtosis model offers no added value to the conventional, monoexponential model. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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