Liver fibrosis: stretched exponential model outperforms mono-exponential and bi-exponential models of diffusion-weighted MRI.
Objectives: To compare the ability of diffusion-weighted imaging (DWI) parameters acquired from three different models for the diagnosis of hepatic fibrosis (HF).Methods: Ninety-five patients underwent DWI using nine b values at 3 T magnetic resonance. The hepatic apparent diffusion coefficient (ADC...
| Publicado en: | European Radiology Vol. 28; no. 7; pp. 2812 - 2823 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129951962&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129951962 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2018 vid: 28 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129951962 129951962 NLM29404771 129951962 10.1007/s00330-017-5292-z NLM29404771 129951962 ppf: 2812 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Liver fibrosis: stretched exponential model outperforms mono-exponential and bi-exponential models of diffusion-weighted MRI. aug: au: Seo, Nieun Chung, Yong Eun Park, Yung Nyun Kim, Eunju Hwang, Jinwoo Kim, Myeong-Jin affil: Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, 03722, Seodaemun-gu, Seoul, Korea sug: subj: Liver Cirrhosis Pathology Epidemiological Research Female Aged Adult Middle Age Magnetic Resonance Imaging Methods Male Models, Biological Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Barthel Index Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: To compare the ability of diffusion-weighted imaging (DWI) parameters acquired from three different models for the diagnosis of hepatic fibrosis (HF).Methods: Ninety-five patients underwent DWI using nine b values at 3 T magnetic resonance. The hepatic apparent diffusion coefficient (ADC) from a mono-exponential model, the true diffusion coefficient (D t ), pseudo-diffusion coefficient (D p ) and perfusion fraction (f) from a biexponential model, and the distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α) from a stretched exponential model were compared with the pathological HF stage. For the stretched exponential model, parameters were also obtained using a dataset of six b values (DDC#, α#). The diagnostic performances of the parameters for HF staging were evaluated with Obuchowski measures and receiver operating characteristics (ROC) analysis. The measurement variability of DWI parameters was evaluated using the coefficient of variation (CoV).Results: Diagnostic accuracy for HF staging was highest for DDC# (Obuchowski measures, 0.770 ± 0.03), and it was significantly higher than that of ADC (0.597 ± 0.05, p < 0.001), D t (0.575 ± 0.05, p < 0.001) and f (0.669 ± 0.04, p = 0.035). The parameters from stretched exponential DWI and D p showed higher areas under the ROC curve (AUCs) for determining significant fibrosis (≥F2) and cirrhosis (F = 4) than other parameters. However, D p showed significantly higher measurement variability (CoV, 74.6%) than DDC# (16.1%, p < 0.001) and α# (15.1%, p < 0.001).Conclusions: Stretched exponential DWI is a promising method for HF staging with good diagnostic performance and fewer b-value acquisitions, allowing shorter acquisition time.Key Points: • Stretched exponential DWI provides a precise and accurate model for HF staging. • Stretched exponential DWI parameters are more reliable than D p from bi-exponential DWI model • Acquisition of six b values is sufficient to obtain accurate DDC and α. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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