Altered segregation between task-positive and task-negative regions in mild traumatic brain injury.
Changes in large-scale brain networks that accompany mild traumatic brain injury (mTBI) were investigated using functional magnetic resonance imaging (fMRI) during the N-back working memory task at two cognitive loads (1-back and 2-back). Thirty mTBI patients were examined during the chronic stage o...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 3; pp. 697 - 710 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129999103&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129999103 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2018 vid: 12 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129999103 129999103 NLM28456880 10.1007/s11682-017-9724-9 NLM28456880 129999103 ppf: 697 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered segregation between task-positive and task-negative regions in mild traumatic brain injury. aug: au: Sours, Chandler Kinnison, Joshua Padmala, Srikanth Gullapalli, Rao P. Pessoa, Luiz affil: Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 South Greene Street, 21201, Baltimore, MD, USA sug: subj: Brain Concussion Physiopathology Brain Memory, Short Term Brain Physiopathology Brain Concussion Magnetic Resonance Imaging Adult Brain Mapping Methods Neural Pathways Middle Age Neural Pathways Physiopathology Female Cognition Male Chronic Disease Clinical Assessment Tools Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Changes in large-scale brain networks that accompany mild traumatic brain injury (mTBI) were investigated using functional magnetic resonance imaging (fMRI) during the N-back working memory task at two cognitive loads (1-back and 2-back). Thirty mTBI patients were examined during the chronic stage of injury and compared to 28 control participants. Demographics and behavioral performance were matched across groups. Due to the diffuse nature of injury, we hypothesized that there would be an imbalance in the communication between task-positive and Default Mode Network (DMN) regions in the context of effortful task execution. Specifically, a graph-theoretic measure of modularity was used to quantify the extent to which groups of brain regions tended to segregate into task-positive and DMN sub-networks. Relative to controls, mTBI patients showed reduced segregation between the DMN and task-positive networks, but increased functional connectivity within the DMN regions during the more cognitively demanding 2-back task. Together, our findings reveal that patients exhibit alterations in the communication between and within neural networks during a cognitively demanding task. These findings reveal altered processes that persist through the chronic stage of injury, highlighting the need for longitudinal research to map the neural recovery of mTBI patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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