Does ventrolateral prefrontal cortex help in searching for the lost key? Evidence from an fNIRS study.

The Key Search Task (KST) is a neuropsychological test that requires strategies for searching a lost key in an imaginary field. This request may involve different cognitive processes as mental imagery and navigation planning. This study was aimed at investigating, by a twenty-channel functional near...

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Publicado en:Brain Imaging & Behavior Vol. 12; no. 3; pp. 785 - 798
Autores principales: Carrieri, Marika, Lancia, Stefania, Bocchi, Alessia, Ferrari, Marco, Piccardi, Laura, Quaresima, Valentina
Formato: Journal Article
Publicado: Springer Nature Jun2018
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Does ventrolateral prefrontal cortex help in searching for the lost key? Evidence from an fNIRS study.
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          Carrieri, Marika
          Lancia, Stefania
          Bocchi, Alessia
          Ferrari, Marco
          Piccardi, Laura
          Quaresima, Valentina
        affil: Department of Life, Health and Environmental Sciences, University of L’Aquila, Via Vetoio, 67100, L’Aquila, Italy
      sug:
        subj:
          Imagination
          Frontal Lobe Physiology
          Executive Function
          Spectroscopy, Near-Infrared
          Spatial Perception
          Behavior
          Female
          Male
          Neuropsychological Tests
          Dominance, Cerebral
          Adult
          Young Adult
          Clinical Assessment Tools
          Scales
          Adult: 19-44 years
          Female
          Male
      ab: The Key Search Task (KST) is a neuropsychological test that requires strategies for searching a lost key in an imaginary field. This request may involve different cognitive processes as mental imagery and navigation planning. This study was aimed at investigating, by a twenty-channel functional near-infrared spectroscopy (fNIRS) system, the hemodynamic response (i.e., oxygenated-hemoglobin (O2Hb) and deoxygenated-hemoglobin (HHb) changes) of the prefrontal cortex in navigation planning. A right ventrolateral prefrontal cortex (rVLPFC) activation during the KST was hypothesized. Thirty-eight volunteers performed the KST and a Control Task (CT), the latter requiring the volunteers to mark the X letter. An activation (i.e., increase/decrease in O2Hb/HHb) of: 1) rVLPFC during the KST execution, and 2) bilateral dorsolateral prefrontal cortex (DLPFC) during the CT execution was found. The present study provides a contribution in localizing the rVLPFC as the critically active region, within the frontal lobes, that was found maximally activated during mental navigation in the mind's eye of healthy participants while performing the KST. Considering the contribution of rVLPFC in spatial navigation, its activation suggests that the KST could be adopted in the clinical routine for investigating navigation planning. Compared to other neuroimaging techniques, fNIRS (with its relatively low physical constraints) contributes to better clarifying the role of rVLPFC in some aspects of human navigation. Therefore, the combined use of the fNIRS and the KST could be considered as an innovative and valid tool to evaluate fundamental functions for everyday life, such as spatial navigation planning.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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