Functional brain networks reconstruction using group sparsity-regularized learning.

Investigating functional brain networks and patterns using sparse representation of fMRI data has received significant interests in the neuroimaging community. It has been reported that sparse representation is effective in reconstructing concurrent and interactive functional brain networks. To date...

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Publicado en:Brain Imaging & Behavior Vol. 12; no. 3; pp. 758 - 771
Autores principales: Zhao, Qinghua, Li, Will X. Y., Jiang, Xi, Lv, Jinglei, Lu, Jianfeng, Liu, Tianming
Formato: Journal Article
Publicado: Springer Nature Jun2018
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Functional brain networks reconstruction using group sparsity-regularized learning.
      aug:
        au:
          Zhao, Qinghua
          Li, Will X. Y.
          Jiang, Xi
          Lv, Jinglei
          Lu, Jianfeng
          Liu, Tianming
        affil: School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China
      sug:
        subj:
          Brain
          Brain Physiology
          Brain Mapping Methods
          Magnetic Resonance Imaging Methods
          Mental Processes
          Reproducibility of Results
          Brain Anatomy and Histology
          Clinical Assessment Tools
          Scales
      ab: Investigating functional brain networks and patterns using sparse representation of fMRI data has received significant interests in the neuroimaging community. It has been reported that sparse representation is effective in reconstructing concurrent and interactive functional brain networks. To date, most of data-driven network reconstruction approaches rarely take consideration of anatomical structures, which are the substrate of brain function. Furthermore, it has been rarely explored whether structured sparse representation with anatomical guidance could facilitate functional networks reconstruction. To address this problem, in this paper, we propose to reconstruct brain networks utilizing the structure guided group sparse regression (S2GSR) in which 116 anatomical regions from the AAL template, as prior knowledge, are employed to guide the network reconstruction when performing sparse representation of whole-brain fMRI data. Specifically, we extract fMRI signals from standard space aligned with the AAL template. Then by learning a global over-complete dictionary, with the learned dictionary as a set of features (regressors), the group structured regression employs anatomical structures as group information to regress whole brain signals. Finally, the decomposition coefficients matrix is mapped back to the brain volume to represent functional brain networks and patterns. We use the publicly available Human Connectome Project (HCP) Q1 dataset as the test bed, and the experimental results indicate that the proposed anatomically guided structure sparse representation is effective in reconstructing concurrent functional brain networks.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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