Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.
Bipolar disorder is characterized by recurring episodes of depression and mania. Defining differences in brain function during these states is an important goal of bipolar disorder research. However, few imaging studies have directly compared brain activity between bipolar mood states. Herein, we co...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 3; pp. 837 - 848 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129999116&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129999116 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2018 vid: 12 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129999116 129999116 NLM28674759 10.1007/s11682-017-9741-8 NLM28674759 129999116 ppf: 837 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states. aug: au: Shaffer, Joseph J. Johnson, Casey P. Fiedorowicz, Jess G. Christensen, Gary E. Wemmie, John A. Magnotta, Vincent A. Shaffer, Joseph J Jr affil: Department of Radiology, University of Iowa, Iowa City, IA, USA sug: subj: Brain Physiopathology Magnetic Resonance Imaging Visual Perception Physiology Brain Bipolar Disorder Physiopathology Bipolar Disorder Female Middle Age Bipolar Disorder Psychosocial Factors Male Brain Mapping Adult Physical Stimulation Affect Clinical Assessment Tools Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Bipolar disorder is characterized by recurring episodes of depression and mania. Defining differences in brain function during these states is an important goal of bipolar disorder research. However, few imaging studies have directly compared brain activity between bipolar mood states. Herein, we compare functional magnetic resonance imaging (fMRI) responses during a flashing checkerboard stimulus between bipolar participants across mood states (euthymia, depression, and mania) in order to identify functional differences between these states. 40 participants with bipolar I disorder and 33 healthy controls underwent fMRI during the presentation of the stimulus. A total of 23 euthymic-state, 16 manic-state, 15 depressed-state, and 32 healthy control imaging sessions were analyzed in order to compare functional activation during the stimulus between mood states and with healthy controls. A reduced response was identified in the visual cortex in both the depressed and manic groups compared to euthymic and healthy participants. Functional differences between bipolar mood states were also observed in the cerebellum, thalamus, striatum, and hippocampus. Functional differences between mood states occurred in several brain regions involved in visual and other sensory processing. These differences suggest that altered visual processing may be a feature of mood states in bipolar disorder. The key limitations of this study are modest mood-state group size and the limited temporal resolution of fMRI which prevents the segregation of primary visual activity from regulatory feedback mechanisms. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|