Functional connectivity density mapping: comparing multiband and conventional EPI protocols.
Functional connectivity density mapping (FCDM) is a newly developed data-driven technique that quantifies the number of local and global functional connections for each voxel in the brain. In this study, we evaluated reproducibility, sensitivity, and specificity of both local functional connectivity...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 3; pp. 848 - 860 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129999117&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129999117 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2018 vid: 12 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129999117 129999117 NLM28676985 129999117 10.1007/s11682-017-9742-7 NLM28676985 129999117 ppf: 848 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Functional connectivity density mapping: comparing multiband and conventional EPI protocols. aug: au: Cohen, Alexander D. Tomasi, Dardo Shokri-Kojori, Ehsan Nencka, Andrew S. Wang, Yang affil: Department of Radiology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA sug: subj: Brain Mapping Methods Magnetic Resonance Imaging Methods Brain Neural Pathways Gray Matter Male Human Young Adult Middle Age Brain Physiology Relaxation Reproducibility of Results Neural Pathways Physiology Gray Matter Physiology Adult Female Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Ferrans and Powers Quality of Life Index Scales Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Functional connectivity density mapping (FCDM) is a newly developed data-driven technique that quantifies the number of local and global functional connections for each voxel in the brain. In this study, we evaluated reproducibility, sensitivity, and specificity of both local functional connectivity density (lFCD) and global functional connectivity density (gFCD). We compared these metrics using the human connectome project (HCP) compatible high-resolution (2 mm isotropic, TR = 0.8 s) multiband (MB), and more typical, lower resolution (3.5 mm isotropic, TR = 2.0 s) single-band (SB) resting state functional MRI (rs-fMRI) acquisitions. Furthermore, in order to be more clinically feasible, only rs-fMRI scans that lasted seven minutes were tested. Subjects were scanned twice within a two-week span. We found sensitivity and specificity increased and reproducibility either increased or did not change for the MB compared to the SB acquisitions. The MB scans also showed improved gray matter/white matter contrast compared to the SB scans. The lFCD and gFCD patterns were similar across MB and SB scans and confined predominantly to gray matter. We also observed a strong spatial correlation of FCD between MB and SB scans indicating the two acquisitions provide similar information. These findings indicate high-resolution MB acquisitions improve the quality of FCD data, and seven minute rs-fMRI scan can provide robust FCD measurements. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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