White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study.
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using co...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 3; pp. 870 - 882 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129999119&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129999119 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2018 vid: 12 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129999119 129999119 NLM28676987 129999119 10.1007/s11682-017-9744-5 NLM28676987 129999119 ppf: 870 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study. aug: au: Lepage, Christian de Pierrefeu, Amicie Koerte, Inga K. Coleman, Michael J. Pasternak, Ofer Grant, Gerald Marx, Christine E. Morey, Rajendra A. Flashman, Laura A. George, Mark S. McAllister, Thomas W. Andaluz, Norberto Shutter, Lori Coimbra, Raul Zafonte, Ross D. Stein, Murray B. Shenton, Martha E. Bouix, Sylvain affil: Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, 1249 Boylston St, 02215, Boston, MA, USA sug: subj: Brain Concussion Stress Disorders, Post-Traumatic Magnetic Resonance Imaging Brain Male Stress Disorders, Post-Traumatic Epidemiology Human Female Brain Concussion Epidemiology Adult Comorbidity Brain Concussion Complications Stress Disorders, Post-Traumatic Complications Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Adult: 19-44 years Male Female ab: Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries. Using a subject-specific approach, we compared fractional anisotropy (FA) abnormalities between groups with a history of mTBI (n = 35), comorbid mTBI and PTSD (mTBI + PTSD; n = 22), and healthy controls (n = 37). We compared all three groups on the number of abnormal FA clusters derived from subject-specific injury profiles (i.e., individual z-score maps) along a common white matter skeleton. The mTBI + PTSD group evinced a greater number of abnormally low FA clusters relative to both the healthy controls and the mTBI group without PTSD (p < .05). Across the groups with a history of mTBI, increased numbers of abnormally low FA clusters were significantly associated with PTSD symptom severity, depression, post-concussion symptoms, and reduced information processing speed (p < .05). These findings highlight the utility of subject-specific microstructural analyses when searching for mTBI-related brain abnormalities, particularly in patients with PTSD. This study also suggests that patients with a history of mTBI and comorbid PTSD, relative to those without PTSD, are at increased risk of FA abnormalities. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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