Neurobiological effect of selective brain cooling after concussive injury.
The search for effective treatment facilitating recovery from concussive injury, as well as reducing risk for recurrent concussion is an ongoing challenge. This study aimed to determine: a) feasibility of selective brain cooling to facilitate clinical symptoms resolution, and b) biological functions...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 3; pp. 891 - 901 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129999125&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129999125 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2018 vid: 12 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129999125 129999125 NLM28712093 10.1007/s11682-017-9755-2 NLM28712093 129999125 ppf: 891 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neurobiological effect of selective brain cooling after concussive injury. aug: au: Walter, Alexa Finelli, Katie Bai, Xiaoxiao Johnson, Brian Neuberger, Thomas Seidenberg, Peter Bream, Timothy Hallett, Mark Slobounov, Semyon affil: Penn State Center for Sport Concussion, Pennsylvania State University, 19 Recreation Building University Park, 16802, University Park, PA, USA sug: subj: Hypothermia, Induced Methods Brain Concussion Etiology Brain Brain Physiopathology Brain Concussion Therapy Athletic Injuries Therapy Adolescence Body Temperature Brain Concussion Athletic Injuries Young Adult Acute Disease Relaxation Magnetic Resonance Imaging Athletic Injuries Physiopathology Pilot Studies Cerebrovascular Circulation Brain Concussion Physiopathology Treatment Outcomes Athletes Prospective Studies Male Female Clinical Assessment Tools Scales Adolescent: 13-18 years Male Female ab: The search for effective treatment facilitating recovery from concussive injury, as well as reducing risk for recurrent concussion is an ongoing challenge. This study aimed to determine: a) feasibility of selective brain cooling to facilitate clinical symptoms resolution, and b) biological functions of the brain within athletes in acute phase of sports-related concussion. Selective brain cooling for 30 minutes using WElkins sideline cooling system was administered to student-athletes suffering concussive injury (n=12; tested within 5±3 days) and those without history of concussion (n=12). fMRI and ASL sequences were obtained before and immediately after cooling to better understanding the mechanism by which cooling affects neurovascular coupling. Concussed subjects self-reported temporary relief from physical symptoms after cooling. There were no differences in the number or strength of functional connections within Default Mode Network (DMN) between groups prior to cooling. However, we observed a reduction in the strength and number of connections of the DMN with other ROIs in both groups after cooling. Unexpectedly, we observed a significant increase in cerebral blood flow (CBF) assessed by ASL after selective cooling in the concussed subjects compared to the normal controls. We suggest that compromised neurovascular coupling in acute phase of injury may be temporarily restored by cooling to match CBF with surges in the metabolic demands of the brain. Upon further validation, selective brain cooling could be a potential clinical tool in the minimization of symptoms and pathological changes after concussion. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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