Interobserver variations in the delineation of target volumes and organs at risk and their impact on dose distribution in intensity-modulated radiation therapy for nasopharyngeal carcinoma.
Objective: This study aimed to (a) assess the differences in the delineation of target volumes and organs-at-risk (OARs) by different physicians designing an intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and (b) analyze the impact of these differences on the treatme...
| Published in: | Oral Oncology Vol. 82; pp. 1 - 8 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Pergamon Press - An Imprint of Elsevier Science
Jul2018
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130226599&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130226599 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13688375 JRJ jtl: Oral Oncology issn: 13688375 maglogo: N pubinfo: dt: Jul2018 vid: 82 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 130226599 130226599 NLM29909882 130226599 10.1016/j.oraloncology.2018.04.025 NLM29909882 130226599 ppf: 1 ppct: 7 formats: tig: atl: Interobserver variations in the delineation of target volumes and organs at risk and their impact on dose distribution in intensity-modulated radiation therapy for nasopharyngeal carcinoma. aug: au: Peng, Ying-lin Chen, Li Shen, Guan-zhu Li, Ya-ning Yao, Ji-jin Xiao, Wei-wei Yang, Lin Zhou, Shu Li, Jia-xin Cheng, Wan-qin Guan, Ying Xia, Hai-qun Liu, Shuai Zhao, Chong Deng, Xiao-wu affil: Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, PR China sug: subj: Nasopharyngeal Neoplasms Radiotherapy Radiation Dosage Radiotherapy, Conformal Methods Observer Bias Tomography, X-Ray Computed Human Aged Radiotherapy, Conformal Adverse Effects Nasopharyngeal Neoplasms Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Impact of Events Scale OARS Multidimensional Functional Assessment Questionnaire Scales Aged: 65+ years Male ab: Objective: This study aimed to (a) assess the differences in the delineation of target volumes and organs-at-risk (OARs) by different physicians designing an intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and (b) analyze the impact of these differences on the treatment plan optimization.Materials and Methods: The planning target volumes (PTVs) and OARs for radiotherapy were manually delineated from computed tomography images of a patient with NPC, and a standard delineation was determined using the STAPLE algorithm of ABAS software. IMRT was designed using one standard plan and 10 individual plans based on the same constraints and field conditions. The maximum/minimum ratio (MMR) of the PTV and OAR volumes and the coefficient of variation (CV) for the different groups were evaluated and compared to the volume of the standard contour.Results: Significant differences were seen in the PTVs of the nasopharynx (PTVnx), neck lymph node (PTVnd) and the OARs manually delineated by different physicians. Compared to the standard plan, the mean dose-related parameters of various OARs in different individual plans were not significantly different, while that of most organs in different individual plans were reduced. However, a significant difference in the dose at each organ was noted in different individual plans.Conclusion: Significant differences were noted in the PTV and OAR delineations by different physicians in radiotherapy of NPC, and their dosimetric parameters were significantly different from the standard planned parameters. Therefore, multicenter trials should pay attention to the impact of these differences on the clinical evaluation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|