Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models.
Purpose: Photodynamic therapy (PDT) is a promising treatment modality to be added in the management of glioblastoma multiforme (GBM). Light distribution modeling is required for planning and optimizing PDT. Several models have been developed to predict the light propagation inside biological tissues...
| Publicado en: | Lasers in Surgery & Medicine Vol. 50; no. 5; pp. 523 - 535 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130245477&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130245477 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01968092 OCY jtl: Lasers in Surgery & Medicine issn: 01968092 maglogo: Y pubinfo: dt: Jul2018 vid: 50 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 130245477 130245477 NLM28906571 10.1002/lsm.22739 NLM28906571 130245477 ppf: 523 ppct: 12 formats: tig: atl: Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models. aug: au: Dupont, Clément Vignion, Anne‐Sophie Mordon, Serge Reyns, Nicolas Vermandel, Maximilien Vignion, Anne-Sophie affil: Univ. Lille, Inserm, CHU Lille, U1189‐ONCO‐THAI‐Image Assisted Laser Therapy for Oncology, Lille, F‐59000, France sug: subj: Brain Neoplasms Drug Therapy Porphyrins Therapeutic Use Photochemotherapy Photosensitizing Agents Therapeutic Use Glioma Drug Therapy Models, Biological Computer Simulation Sensitivity and Specificity Systems Analysis Algorithms ab: Purpose: Photodynamic therapy (PDT) is a promising treatment modality to be added in the management of glioblastoma multiforme (GBM). Light distribution modeling is required for planning and optimizing PDT. Several models have been developed to predict the light propagation inside biological tissues. In the present study, two analytical methods of light propagation emitted from a cylindrical fiber source were evaluated: a discrete and a continuous method.Methods: The two analytical approaches were compared according to their fluence rate results. Several cylindrical diffuse lengths were evaluated, and the relative deviation in the fluence rates was estimated. Moreover, a sensitivity analysis was conducted to compute the variance of each analytical model.Results: The discrete method provided fluence rate estimations closer to the Monte-Carlo simulations than the continuous method. The sensitivity study results did not reveal significant differences between the variance of the two analytical models.Conclusions: Although the discrete model provides relevant light distribution, the heterogeneity of GBM tissues was not considered. With the improvement in parallel computing that drastically decreased the computing time, replacing the analytical model by a Monte-Carlo GPU-accelerated code appeared relevant to the GBM case. Nonetheless, the analytical modeling may still function in the optimization algorithms, which might be used in the Photodynamic treatment planning system. Lasers Surg. Med. 50:523-534, 2018. © 2017 Wiley Periodicals, Inc. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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