Schützende Wirkung einer systemischen Behandlung mit Dermatansulfat in einem präklinischen Modell strahleninduzierter oraler Mukositis.
Purpose: Oral mucositis is a frequent, dose-limiting side effect of radio(chemo)therapy of head-and-neck malignancies. The epithelial radiation response is based on multiple tissue changes, which could offer targets for a biologically tailored treatment. The potential of dermatan sulfate (DS) to mod...
| Publicado en: | Strahlentherapie und Onkologie Vol. 194; no. 7; pp. 675 - 686 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130276430&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130276430 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01797158 NZE jtl: Strahlentherapie und Onkologie issn: 01797158 maglogo: N pubinfo: dt: Jul2018 vid: 194 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130276430 130276430 NLM29497792 10.1007/s00066-018-1280-8 NLM29497792 130276430 ppf: 675 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Schützende Wirkung einer systemischen Behandlung mit Dermatansulfat in einem präklinischen Modell strahleninduzierter oraler Mukositis. aug: au: Gruber, Sylvia Frings, Katharina Kuess, Peter Dörr, Wolfgang affil: Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria sug: subj: Radiation Injuries Prevention and Control Tongue Radiation Effects Otorhinolaryngologic Neoplasms Radiotherapy Stomatitis Prevention and Control Chondroitin Pharmacodynamics Models, Biological Radiation Dosage Mice Injections, Subcutaneous Animals Dose-Response Relationship, Radiation Male Male ab: Purpose: Oral mucositis is a frequent, dose-limiting side effect of radio(chemo)therapy of head-and-neck malignancies. The epithelial radiation response is based on multiple tissue changes, which could offer targets for a biologically tailored treatment. The potential of dermatan sulfate (DS) to modulate radiation-induced oral mucositis was tested in an established preclinical mucositis model.Methods: Irradiation was either applied alone or in combination with daily DS treatment (4 mg/kg, subcutaneously) over varying time intervals. Irradiation comprised single dose irradiation with graded doses to the lower tongue surface or daily fractionated irradiation of the whole tongue. Fractionation protocols (5 × 3 Gy/week) over one (days 0-4) or two weeks (days 0-4, 7-11) were terminated by an additional local single dose irradiation to a defined treatment field on the lower tongue surface to induce the mucosal radiation response. The additional single dose irradiation (top-up) on day 7 (after one week of fractionation) or day 14 (after 2 weeks of fractionation) comprised graded doses in order to generate full dose-effect curves. Ulceration of the epithelium of the lower tongue, corresponding to confluent mucositis, was analysed as clinically relevant endpoint. Additionally, the time course parameters, latent time and ulcer duration were analysed.Results: DS treatment significantly reduced the incidence of ulcerations. DS application over longer time intervals resulted in a more pronounced reduction of ulcer frequency, increased latent times and reduced ulcer duration.Conclusion: DS has a significant mucositis-ameliorating activity with pronounced effects on mucositis frequency as well as on time course parameters. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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