Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects.

Background: Aberrant glutamate neurotransmission, and in particular dysfunction of the N-methyl-D-aspartate receptor (NMDAR), has been implicated in psychiatric disorders and represents a novel therapeutic target. Low-dose administration of the NMDA antagonist ketamine in healthy volunteers elicits...

Descripción completa

Detalles Bibliográficos

Publicado en:	Psychopharmacology Vol. 235; no. 7; pp. 1875 - 1887
Autores principales:	Mehta, Mitul A., Schmechtig, Anne, Kotoula, Vasileia, McColm, Juliet, Jackson, Kimberley, Brittain, Claire, Tauscher-Wisniewski, Sitra, Kinon, Bruce J., Morrison, Paul D., Pollak, Thomas, Mant, Timothy, Williams, Steven C. R., Schwarz, Adam J.
Formato:	Journal Article
Publicado:	Springer Nature Jul2018
Acceso en línea:	Ver este registro en EBSCOhost