Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders.
Background: Distinguishing between urinary tract infection (UTI) and colonization (UTC) in patients with neurogenic bladders who require clean intermittent catheterization (CIC) is difficult. Urinary neutrophil gelatinase-associated lipocalin concentrations (uNGAL) are increased in UTIs. Our objecti...
| Publicado en: | Pediatric Nephrology Vol. 33; no. 8; pp. 1365 - 1375 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130360585&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130360585 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Aug2018 vid: 33 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130360585 130360585 130360585 10.1007/s00467-018-3936-0 130360585 ppf: 1365 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders. aug: au: Forster, Catherine S. Ma, Qing Bennett, Michael Shah, Samir S. Goldstein, Stuart L. Jackson, Elizabeth affil: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, 45229, Cincinnati, OH, USA sug: subj: Urinary Tract Infections Diagnosis Bladder, Neurogenic Therapy Urinary Catheterization, Intermittent Neutrophils Peptide Hydrolases Carrier Proteins Urine Cross Sectional Studies Human ROC Curve Leukocytes Abdominal Pain Back Pain Urinary Incontinence Creatinine Blood Confidence Intervals Sensitivity and Specificity Child Child: 6-12 years ab: Background: Distinguishing between urinary tract infection (UTI) and colonization (UTC) in patients with neurogenic bladders who require clean intermittent catheterization (CIC) is difficult. Urinary neutrophil gelatinase-associated lipocalin concentrations (uNGAL) are increased in UTIs. Our objective was to determine the predictive accuracy of uNGAL for UTI in CIC-dependent children.Methods: Cross-sectional study of CIC-dependent patients from August, 2015 to November, 2016. UTI was defined as (1) growth of ≥ 50,000 cfu/mL of a uropathogen, (2) > 10 urinary white blood cells/hpf, and (3) ≥ 2 of the following: temperature > 38 °C, abdominal pain, back pain, worsened incontinence, pain with catheterization, or malodorous/cloudy urine. Positive urine cultures that did not meet these criteria were grouped as UTC, and negative cultures were grouped as no growth.Results: Two hundred one patients were included (no growth = 100, UTC = 77, UTI = 24). Median (interquartile range) uNGAL was higher in the UTI group (UTI 1361 (931, 2516) μg/g creatinine, UTC 246 (106, 548) μg/g creatinine, no growth 36 (11, 179) μg/g creatinine, p < 0.01 for all comparisons). The area under the ROC curve for uNGAL for UTI versus no UTI was 0.89, 95% CI (0.80-0.98).Conclusion: uNGAL is elevated in CIC-dependent children with UTI compared to those with negative cultures and those with UTC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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