Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings.
Alcohol's multisystemic effects impact HIV disease pathogenesis and increase the risk for comorbidities in persons living with HIV (PLWH). The increased number of aging PLWH increases the potential for alcohol to enhance the risk for comorbidities. Integration of epidemiological, preclinical and tra...
| Publicado en: | Alcohol & Alcoholism Vol. 53; no. 4; pp. 439 - 448 |
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| Autores principales: | , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130371590&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130371590 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jul2018 vid: 53 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 130371590 130371590 130371590 10.1093/alcalc/agy016 130371590 ppf: 439 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings. aug: au: Molina, Patricia E. Simon, Liz Amedee, Angela M. Welsh, David A. Ferguson, Tekeda F. affil: Comprehensive Alcohol-HIV/AIDS Research Center and Alcohol and Drug Abuse Center of Excellence, LSUHSC, 1901 Perdido St., New Orleans, LA 70112, USA sug: subj: Alcohol Drinking Comorbidity Risk Factors Aging HIV-Positive Persons Severity of Illness HIV Infections Risk Factors HIV Infections Drug Therapy Economic Aspects of Illness Quality of Life Health Care Costs Antiretroviral Therapy, Highly Active Survival HIV Infections Prognosis ab: Alcohol's multisystemic effects impact HIV disease pathogenesis and increase the risk for comorbidities in persons living with HIV (PLWH). The increased number of aging PLWH increases the potential for alcohol to enhance the risk for comorbidities. Integration of epidemiological, preclinical and translational studies provide an overarching view of the impact of heavy alcohol consumption on HIV risk, pathogenesis, treatment and burden of disease. The combined insult of HIV infection, heavy alcohol consumption and toxic effects of antiretroviral therapy in aging PLWH poses a public health challenge through increased disease burden that also impacts quality of life and increases health care costs. Herein we provide a brief overview of current knowledge on alcohol's impact on HIV disease pathogenesis, with focus on aging PLWH. Short Summary: Effective combined antiretroviral therapy regimens have extended survival of persons living with HIV (PLWH). Heavy alcohol consumption is common in PLWH. This overview integrates evidence from clinical and preclinical research to identify salient alcohol-related mechanisms and comorbidities contributing to disease pathogenesis and accelerated aging and senescence in PLWH. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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