Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest.

Temozolomide (TMZ) is the first-line chemotherapeutic agent in the treatment of glioblastoma multiforme (GBM). Despite its cytotoxic effect, TMZ also induces cell cycle arrest that may lead to the development of chemoresistance and eventual tumor recurrence. Caffeine, a widely consumed neurostimulan...

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Publicado en:	BioMed Research International Vol. 2018; pp. 1 - 11
Autores principales:	Li, Ning, Zhang, Pingde, Kiang, Karrie Mei Yee, Cheng, Yin Stephen, Leung, Gilberto Ka Kit
Formato:	pictorial research tables/charts Journal Article
Publicado:	Wiley-Blackwell 6/28/2018
Acceso en línea:	Ver este registro en EBSCOhost