بیان LncRNA HOX transcript antisense RNA در بیماران تازه تشخیص داده شده لوسمی لنفوبلاستیک حاد
Background and Objectives Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. The prevalence of ALL is 1 to 4/7 per 100,000 population every year world-wide. Long non-coding RNAs (LncRNAs) are a group of non-coding RNAs involved in many biological processes, such as epigen...
| Publicado en: | Scientific Journal of Iranian Blood Transfusion Organization Vol. 15; no. 1; pp. 28 - 36 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Iranian Blood Transfusion Organization Research Center
Spring2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130382402&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130382402 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10279520 BO1X jtl: Scientific Journal of Iranian Blood Transfusion Organization issn: 10279520 maglogo: N pubinfo: dt: Spring2018 vid: 15 iid: 1 pid: 71354 pub: Iranian Blood Transfusion Organization Research Center artinfo: ui: 130382402 130382402 ppf: 28 ppct: 8 formats: tig: atl: بیان LncRNA HOX transcript antisense RNA در بیماران تازه تشخیص داده شده لوسمی لنفوبلاستیک حاد aug: au: فلاح, پرویز ملایی, مجتبی حیدری, علی احسان سلیمانی, مسعود جاهدی برزگر, مهدی عارفیان, احسان مدنی, طاهره اسدی, موژان پوپک, بهزاد affil: دانشگاه علوم پزشکی همدان، دانشکده بهداشت، دانشگاه علوم پزشکی البرز، کرج، ایران sug: subj: Blood Transfusion ab: Background and Objectives Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. The prevalence of ALL is 1 to 4/7 per 100,000 population every year world-wide. Long non-coding RNAs (LncRNAs) are a group of non-coding RNAs involved in many biological processes, such as epigenetic changes, regulation of mRNA transcription and translation. Identification of their function can be helpful to understand the pathophysiology and treatment of ALL. One of the important LncRNAs in hematopoiesis regulation is HOTAIR (LncRNA HOX transcript antisense RNA). The purpose of this study was to determine the expression of HOTAIR LncRNA in newly diagnosed B-ALL patients. Materials and Methods In this cross-sectional descriptive study, 40 newly diagnosed B-ALL patients as well as 15 healthy individuals as control were given 1mL of bone marrow specimen with EDTA anticoagulant. RNA (patients and control) was extracted and Real-time quantitative PCR was used to examine the expression of LncRNA HOTAIR in ALL patients. The results was analyzed by REST 2009. Results The findings showed that expression of HOTAIR in patients with Acute Lymphoblastic Leukemia type B increased significantly as compared to healthy controls (p ˂ 0.05). Conclusions In conclusion, the increase expression of HOTAIR in acute lymphoblastic leukemia can be attributed to potential role of LncRNA HOTAIR in pathophysiology of the disease. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: Persian refInfo: holdings: @attributes: islocal: N |
|---|