Phenolic Constituents and Inhibitory Effects of Hibiscus sabdariffa L. (Sorrel) Calyx on Cholinergic, Monoaminergic, and Purinergic Enzyme Activities.
This study revealed the effect of phenolic extract from Hibiscus sabdariffa L. (sorrel) calyx on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and ecto-5′ nucleotidase (E-NTDase) activities as well as pro-oxidant-induced oxidative damage in rat brain in vitro. S...
| Publicado en: | Journal of Dietary Supplements Vol. 15; no. 6; pp. 910 - 923 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130443588&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130443588 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: 2018 vid: 15 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 130443588 130443588 130443588 10.1080/19390211.2017.1406426 130443588 ppf: 910 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Phenolic Constituents and Inhibitory Effects of Hibiscus sabdariffa L. (Sorrel) Calyx on Cholinergic, Monoaminergic, and Purinergic Enzyme Activities. aug: au: Oboh, Ganiyu Adewuni, Taiwo M. Ademiluyi, Adedayo O. Olasehinde, Tosin A. Ademosun, Ayokunle O. affil: Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria sug: subj: Hibiscus Pharmacodynamics Receptors, Cholinergic Drug Effects Neurotransmitters Drug Effects Phenols Antagonists and Inhibitors Flowers Pharmacodynamics Plant Extracts Pharmacodynamics Human Acetylcholinesterase Drug Effects Cholinesterases Drug Effects Monoamine Oxidase Inhibitors Drug Effects Hydrolases Drug Effects In Vitro Studies Rats Brain Drug Effects Nitroprusside Malondialdehyde Flavonoids Acids, Carbocyclic Rutin Neurodegenerative Diseases Diet Therapy Alzheimer's Disease Diet Therapy Parkinson Disease Diet Therapy Iron Adenosine Triphosphatase Drug Effects ab: This study revealed the effect of phenolic extract from Hibiscus sabdariffa L. (sorrel) calyx on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and ecto-5′ nucleotidase (E-NTDase) activities as well as pro-oxidant-induced oxidative damage in rat brain in vitro. Sorrel extract inhibited AChE (EC50 = 46.96 µg/mL), BChE (EC50 = 40.38 µg/mL), MAO (EC50 = 43.69 µg/mL), and E-NTDase (EC50 = 40.52 µg/mL) and stimulated Na+/K+-ATPase (EC50 = 22.01 µg/mL) activities. The phenolic extract also reduced Fe2+- (EC50 = 22.37 µg/mL) and sodium nitroprusside- (SNP-) (21.46 µg/mL) induced malondialdehyde (MDA) production in rat brain homogenates. Catechin (53.12 mg/g), chlorogenic (67.12 mg/g), rutin (16.25 mg/g), and caffeic acid (15.38 mg/g) were the most abundant phenolic compounds in the extract. The synergistic effects of the phenolic compounds may contribute to the enzyme inhibitory and stimulatory activities of the extract. Our findings suggest that sorrel extract shows promising potential for the treatment and/or management of some neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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