Treatment of cryptococcosis in non-HIV immunocompromised patients.
Purpose Of Review: Cryptococcosis has become a common opportunistic infection among non-HIV immunocompromised hosts. Recent reports have shown the incidence of Cryptococcosis among HIV-negative immunocompromised patients reaches close to half of the overall cases reported in the USA. Management of t...
| Publicado en: | Current Opinion in Infectious Diseases Vol. 31; no. 4; pp. 278 - 286 |
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| Autores principales: | , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130497211&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130497211 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09517375 IQU jtl: Current Opinion in Infectious Diseases issn: 09517375 maglogo: N pubinfo: dt: Aug2018 vid: 31 iid: 4 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 130497211 130497211 NLM29738314 130497211 10.1097/QCO.0000000000000458 NLM29738314 130497211 ppf: 278 ppct: 8 formats: tig: atl: Treatment of cryptococcosis in non-HIV immunocompromised patients. aug: au: Henao-Martínez, Andrés F. Chastain, Daniel B. Franco-Paredesa, Carlos Franco-Paredes, Carlos affil: Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado sug: subj: Cryptococcosis Therapy Cryptococcus Immunology Cryptococcosis Etiology Immunocompromised Host Recurrence Cryptococcosis Diagnosis Meningitis, Cryptococcal Therapy Meningitis, Cryptococcal Etiology Antifungal Agents Therapeutic Use Antifungal Agents Adverse Effects Meningitis, Cryptococcal Diagnosis Cryptococcosis Prevention and Control Antifungal Agents Administration and Dosage ab: Purpose Of Review: Cryptococcosis has become a common opportunistic infection among non-HIV immunocompromised hosts. Recent reports have shown the incidence of Cryptococcosis among HIV-negative immunocompromised patients reaches close to half of the overall cases reported in the USA. Management of this infection in this population carries unique challenges. We aim to review relevant and recent research findings to develop treatment recommendations for this type of population.Recent Findings: Most of the recommendations for the management of non-HIV immunocompromised host are extrapolated from HIV studies. Cryptococcosis among non-HIV patients is common but often overlooked. Some clinical factors, when present, may increase the risk of Cryptococcosis among HIV-negative patients and appropriate screening and assessment for the disease is necessary. Treating clinicians should consider a longer duration of induction with Amphotericin B depending on the type of host, immunocompromised state, antifungal response and presence of neurological complications. Baseline fluconazole resistance can reach up to 12%, which is an important consideration for cryptococcal meningitis relapses or suboptimal responses to therapy.Summary: Cryptococcus spp. conveys a high disease burden among immunocompromised hosts. Clinicians must consider numerous variables and factors in a dynamic way to offer the best possible treatment and to monitor their response to therapy. Due to the high cost and associated toxicities, we still need new affordable therapies and studies among non-HIV immunocompromised patients. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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