Diagnostic evaluation of magnetization transfer and diffusion kurtosis imaging for prostate cancer detection in a re-biopsy population.
Objective: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population.Methods: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and M...
| Publicado en: | European Radiology Vol. 28; no. 8; pp. 3141 - 3151 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130553004&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130553004 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2018 vid: 28 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130553004 130553004 NLM29222677 130553004 10.1007/s00330-017-5169-1 NLM29222677 130553004 ppf: 3141 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diagnostic evaluation of magnetization transfer and diffusion kurtosis imaging for prostate cancer detection in a re-biopsy population. aug: au: Barrett, Tristan McLean, Mary Priest, Andrew N. Lawrence, Edward M. Patterson, Andrew J. Koo, Brendan C. Patterson, Ilse Warren, Anne Y. Doble, Andrew Gnanapragasam, Vincent J. Kastner, Christof Gallagher, Ferdia A. affil: Department of Radiology, University of Cambridge, Cambridge, UK sug: subj: Prostatic Neoplasms Pathology ROC Curve Magnetic Resonance Imaging Methods Prospective Studies Repeat Procedures Male Middle Age Human Image Interpretation, Computer Assisted Methods Aged Biopsy Methods Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Middle Aged: 45-64 years Aged: 65+ years Male ab: Objective: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population.Methods: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics.Results: Twenty patients had ≥ 1 core positive for cancer in a total of 26 MRI targets (Gleason 3+3 in 8, 3+4 in 12, ≥ 4+3 in 6): 13 peripheral (PZ) and 13 transition zone (TZ). The apparent diffusion coefficient (ADC) and Dapp were significantly lower and the Kapp and MT ratio (MTR) significantly higher in tumour versus benign tissue (all p ≤ 0.005); ROC values 0.767-1.000. Normal TZ had: lower ADC and Dapp and higher Kapp and MTR compared to normal PZ. MTR showed a moderate correlation to Kapp (r = 0.570) and Dapp (r = -0.537) in normal tissue but a poor correlation in tumours. No parameter separated low-grade (Gleason 3+3) from high-grade (≥ 3+4) disease for either PZ (p = 0.414-0.825) or TZ (p = 0.148-0.825).Conclusion: ADC, Dapp, Kapp and MTR all distinguished benign tissue from tumour, but none reliably differentiated low- from high-grade disease.Key Points: • MTR was significantly higher in PZ and TZ tumours versus normal tissue • K app was significantly lower and D app higher for PZ and TZ tumours • There was no incremental value for DKI/MTI over mono-exponential ADC parameters • No parameter could consistently differentiate low-grade (Gleason 3+3) from high-grade (≥ 3+4) disease • Divergent MTR/DKI values in TZ tumours suggests they offer different functional information. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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