Angiosomal radiopathologic analysis of transarterial radioembolization for the treatment of hepatocellular carcinoma.
Purpose: To assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response.Methods: Twelve patients with HCC underwent ablative (≥ 190 Gy) and/or...
| Publicado en: | Abdominal Radiology Vol. 43; no. 7; pp. 1825 - 1837 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130627389&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130627389 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jul2018 vid: 43 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130627389 10.1007/s00261-017-1354-6 130627389 ppf: 1825 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Angiosomal radiopathologic analysis of transarterial radioembolization for the treatment of hepatocellular carcinoma. aug: au: Ahmed, Altan F. Grajo, Joseph R. Sistrom, Chris L. Shah, Jehan L. Geller, Brian S. Samreen, Naziya Toskich, Beau B. Zendejas, Ivan Collinsworth, Amy Esnakula, Ashwini Cabrera, Roniel affil: Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA sug: ab: Purpose: To assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response.Methods: Twelve patients with HCC underwent ablative (≥ 190 Gy) and/or non-ablative (< 190 Gy) TARE delivered in a segmental, lobar, or combined fashion as a surgical neoadjuvant or bridge to transplantation. Both targeted tumor and treatment angiosome were analyzed before and after TARE utilizing hepatocyte-specific contrast-enhanced MRI or contrast-enhanced CT. Responses were graded using EASL and mRECIST criteria. Histologic findings including percent tumor necrosis and adjacent hepatic substrate effects were correlated with imaging features.Results: Complete pathologic necrosis (CPN) was observed in 7/12 tumors post-TARE. Ablative and non-ablative dosing resulted in CPN in 5/6 and 2/6 tumors, respectively. Hyperintensity on T2-weighted imaging, the absence of hepatocyte-specific gadolinium contrast uptake, and plateau or persistent enhancement kinetics in the angiosome correlated with CPN and performed similarly to EASL and mRECIST criteria in predicting CPN.Conclusions: The absence of hepatocyte-specific contrast uptake, increased signal on T2-weighted sequences, and plateau or persistent enhancement in the angiosome may represent MRI surrogates of CPN following TARE of HCC. These findings correlated with EASL and mRECIST response criteria. Further investigation is needed to determine the role of these findings as possible adjuncts to conventional imaging criteria. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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