Sex‐specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population.
Background: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that f...
| Publicado en: | Journal of Child Psychology & Psychiatry Vol. 59; no. 8; pp. 908 - 917 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Aug2018
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=130627911&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 130627911 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00219630 JYY jtl: Journal of Child Psychology & Psychiatry issn: 00219630 maglogo: Y pubinfo: dt: Aug2018 vid: 59 iid: 8 pid: 480 pub: Wiley-Blackwell artinfo: ui: 130627911 10.1111/jcpp.12874 ppf: 908 ppct: 9 formats: tig: atl: Sex‐specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population. aug: au: Martin, Joanna Taylor, Mark J. Rydell, Mina Riglin, Lucy Eyre, Olga Lu, Yi Lundström, Sebastian Larsson, Henrik Thapar, Anita Lichtenstein, Paul affil: Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK Institute of Neuroscience and Physiology, Gillberg Neuropsychiatry Centre, Centre for Ethics Law and Mental Health, University of Gothenburg, Gothenburg, Sweden School of Medical Sciences, Örebro University, Örebro, Sweden su: Diagnosis of mental depression Risk factors of attention-deficit hyperactivity disorder Attention-deficit hyperactivity disorder Medical screening Sex distribution Genetics Anxiety diagnosis Algorithms Confidence intervals Genetic polymorphisms Longitudinal method Odds ratio Symptoms sug: subj: Diagnosis of mental depression Risk factors of attention-deficit hyperactivity disorder Attention-deficit hyperactivity disorder Medical screening Sex distribution Genetics All Other Miscellaneous Ambulatory Health Care Services Anxiety diagnosis Algorithms Confidence intervals Genetic polymorphisms Longitudinal method Odds ratio Symptoms keyword: ADHD ALSPAC anxiety CATSS depression genetics ADHD ALSPAC anxiety CATSS depression genetics ab: Background: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD, requiring a higher burden of genetic risk to manifest the disorder. Methods: We tested these two hypotheses, using common variant genetic data from two population‐based cohorts. First, we tested whether females and males diagnosed with anxiety or depression differ in terms of their genetic risk for ADHD, assessed as polygenic risk scores (PRS). Second, we tested whether females and males with ADHD differed in ADHD genetic risk burden. We used three different diagnostic definitions: registry‐based clinical diagnoses, screening‐based research diagnoses and algorithm‐based research diagnoses, to investigate possible referral biases. Results: In individuals with a registry‐based clinical diagnosis of anxiety or depression, females had higher ADHD PRS than males [OR(CI) = 1.39 (1.12–1.73)] but there was no sex difference for screening‐based [OR(CI) = 1.15 (0.94–1.42)] or algorithm‐based [OR(CI) = 1.04 (0.89–1.21)] diagnoses. There was also no sex difference in ADHD PRS in individuals with ADHD diagnoses that were registry‐based [OR(CI) = 1.04 (0.84–1.30)], screening‐based [OR(CI) = 0.96 (0.85–1.08)] or algorithm‐based [OR(CI) = 1.15 (0.78–1.68)]. Conclusions: This study provides genetic evidence that ADHD risk may be more likely to manifest or be diagnosed as anxiety or depression in females than in males. Contrary to some earlier studies, the results do not support increased ADHD genetic risk in females with ADHD as compared to affected males. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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