Coupled Imaging with [18F]FBB and [18F]FDG in AD Subjects Show a Selective Association Between Amyloid Burden and Cortical Dysfunction in the Brain.
Purpose: The present study was aimed to investigate the relationships between dysfunction of cortical glucose metabolism as detectable by means of 2-deoxy-2-[18F]fluoro -D-glucose ([18F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) and amyloid burden as detectable by means of...
| Publicado en: | Molecular Imaging & Biology Vol. 20; no. 4; pp. 659 - 667 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130645760&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130645760 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Aug2018 vid: 20 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130645760 130645760 NLM29404839 130645760 10.1007/s11307-018-1167-1 NLM29404839 130645760 ppf: 659 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Coupled Imaging with [18F]FBB and [18F]FDG in AD Subjects Show a Selective Association Between Amyloid Burden and Cortical Dysfunction in the Brain. aug: au: Chiaravalloti, Agostino Castellano, Anna Elisa Ricci, Maria Barbagallo, Gaetano Sannino, Pasqualina Ursini, Francesco Karalis, Georgios Schillaci, Orazio affil: Department of Biomedicine and Prevention, University Tor Vergata, Viale Oxford 81, 00133, Rome, Italy sug: subj: Fludeoxyglucose F 18 Alzheimer's Disease Physiopathology Stilbenes Amines Cerebral Cortex Physiopathology Proteins Metabolism Alzheimer's Disease Regression Case Control Studies Imaging, Three-Dimensional Aged Male Female Human Aged: 65+ years Male Female ab: Purpose: The present study was aimed to investigate the relationships between dysfunction of cortical glucose metabolism as detectable by means of 2-deoxy-2-[18F]fluoro -D-glucose ([18F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) and amyloid burden as detectable by means of 4-{(E)-2-[4-(2-{2-[2-[18F]fluoroethoxy]ethoxy}ethoxy)phenyl]vinyl}-N-methylaniline (florbetaben; [18F]FBB) in a group of patients affected by Alzheimer's disease (AD).Procedures: We examined 38 patients newly diagnosed with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a PET/CT scan using both [18F]FDG and [18F]FBB with an average interval of 1 month. We used statistical parametric mapping (SPM8) implemented in Matlab R2012b and WFU pickatlas for the definition of a region of interest (ROI) mask including the whole cortex. These data were then normalized on the counts of the cerebellum and then used for a regression analysis on [18F]FDG scans in SPM. Furthermore, 58 control subjects were used as control group for [18F]FDG PET/CT scans.Results: SPM analysis in AD patients showed a significant negative correlation between [18F] FBB and [18F] FDG uptake in temporal and parietal lobes bilaterally. Of note, these areas in AD patients displayed a marked glucose hypometabolism compared to control group.Conclusions: Combined imaging with [18F]FBB and [18FFDG shows that amyloid burden in the brain is related to cortical dysfunction of temporal and parietal lobes in AD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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