Serum pepsinogen levels indicate the requirement of upper gastrointestinal endoscopy among Group A subjects of ABC classification: a multicenter study.
Background: ABC classification has been used to assess the risk for gastric cancer. The current problem of ABC classification is that Group A contains individuals with current and past H. pylori infection. The aims of this study were to assesse the proportion of current and past infection in Group A...
| Publicado en: | Journal of Gastroenterology Vol. 53; no. 8; pp. 924 - 932 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130694266&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130694266 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: Aug2018 vid: 53 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130694266 130694266 NLM29353347 130694266 10.1007/s00535-018-1431-9 NLM29353347 130694266 ppf: 924 ppct: 8 formats: tig: atl: Serum pepsinogen levels indicate the requirement of upper gastrointestinal endoscopy among Group A subjects of ABC classification: a multicenter study. aug: au: Chinda, Daisuke Shimoyama, Tadashi Mikami, Tatsuya Arai, Tetsu Chiba, Daisuke Sasaki, Yoshio Komai, Kazuo Sawada, Yoshihiko Saito, Yoshiharu Chiba, Hironobu Fukuda, Shinsaku RINGO Study Group affil: Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan sug: subj: Endoscopy, Gastrointestinal Enzymes Blood Stomach Neoplasms Helicobacter Pylori Immunology Helicobacter Infections Blood Stomach Neoplasms Blood Young Adult Female Breath Tests Feces Aged Middle Age ROC Curve Antigens, Bacterial Analysis Adult Helicobacter Infections Diagnosis Aged, 80 and Over Human Risk Assessment Methods Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Aged, 80 & over Female Male ab: Background: ABC classification has been used to assess the risk for gastric cancer. The current problem of ABC classification is that Group A contains individuals with current and past H. pylori infection. The aims of this study were to assesse the proportion of current and past infection in Group A and to establish a criteria for the identification of subjects with past infection from Group A subjects with negative results of urea breath test (UBT) and/or stool antigen test.Methods: 201 subjects classified into Group A received UBT and/or stool antigen test, and also subsequent upper gastrointestinal endoscopy. The subjects were classified by the status of H. pylori infection defined by endoscopic findings. Levels of pepsinogen (PG) I, PG II and PG I/II ratio were compared between the groups, and receiver operating characteristic curves were constructed to extract the corresponding cutoff values.Results: 22 subjects were tested positive by UBT and/or stool antigen test. Endoscopic images of 157 out of 179 subjects were studied. 15 of the subjects were regarded to have past H. pylori infection. The optimal cut-off value of PG I and PG I/II ratio for the determination of past H. pylori infection were ≤ 31.2 ng/mL and ≤ 4.6, respectively.Conclusions: Approximately 20% of Group A subjects have current or past H. pylori infection. Addition of UBT and/or stool antigen test can identify current but not past infection. Serum PG levels would be useful to identify subjects with past H. pylori infection. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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