Brain-Derived Neurotrophic Factor Modulates Intestinal Barrier by Inhibiting Intestinal Epithelial Cells Apoptosis in Mice.

We aimed to investigate the effects of brain-derived neurotrophic factor (BDNF) on apoptosis of intestinal epithelial cells (IECs) and alterations of intestinal barrier integrity using BDNF knock-out mice model. Colonic tissues from BDNF+/+ mice and BDNF+/- mice were prepared for this study. The int...

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Bibliographic Details
Published in:Physiological Research Vol. 67; no. 3; pp. 475 - 486
Main Authors: Dong-Yan ZHAO, Wen-Xue ZHANG, Qing-Qing QI, Xin LONG, Xia LI, Yan-Bo YU, Xiu-Li ZUO
Format: Journal Article
Published: Institute of Physiology, Academy of Sciences of the Czech Republic 2018
Online Access:View this record in EBSCOhost