Discovering and identifying New York heart association classification from electronic health records.

Background: Cardiac Resynchronization Therapy (CRT) is an established pacing therapy for heart failure patients. The New York Heart Association (NYHA) class is often used as a measure of a patient's response to CRT. Identifying NYHA class for heart failure (HF) patients in an electronic health recor...

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Published in:BMC Medical Informatics & Decision Making Vol. 18; no. 2
Main Authors: Zhang, Rui, Ma, Sisi, Shanahan, Liesa, Munroe, Jessica, Horn, Sarah, Speedie, Stuart
Format: research Journal Article
Published: BioMed Central 7/23/2018 Supplement2
Online Access:View this record in EBSCOhost
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      dt: 7/23/2018 Supplement2
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      pub: BioMed Central
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        130871050
        10.1186/s12911-018-0625-7
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        130871050
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        atl: Discovering and identifying New York heart association classification from electronic health records.
      aug:
        au:
          Zhang, Rui
          Ma, Sisi
          Shanahan, Liesa
          Munroe, Jessica
          Horn, Sarah
          Speedie, Stuart
        affil: Institute for Health Informatics University of Minnesota Minneapolis MN USA
      sug:
        subj:
          Natural Language Processing
          Heart Failure Classification
          Human
          Disease Progression
          New York
          Middle Age
          Cardiac Resynchronization Therapy
          Female
          Treatment Outcomes
          Aged
          Male
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
          Scales
          Middle Aged: 45-64 years
          Aged: 65+ years
          Female
          Male
      ab: Background: Cardiac Resynchronization Therapy (CRT) is an established pacing therapy for heart failure patients. The New York Heart Association (NYHA) class is often used as a measure of a patient's response to CRT. Identifying NYHA class for heart failure (HF) patients in an electronic health record (EHR) consistently, over time, can provide better understanding of the progression of heart failure and assessment of CRT response and effectiveness. Though NYHA is rarely stored in EHR structured data, such information is often documented in unstructured clinical notes.Methods: We accessed HF patients' data in a local EHR system and identified potential sources of NYHA, including local diagnosis codes, procedures, and clinical notes. We further investigated and compared the performances of rule-based versus machine learning-based natural language processing (NLP) methods to identify NYHA class from clinical notes.Results: Of the 36,276 patients with a diagnosis of HF or a CRT implant, 19.2% had NYHA class mentioned at least once in their EHR. While NYHA class existed in descriptive fields association with diagnosis codes (31%) or procedure codes (2%), the richest source of NYHA class was clinical notes (95%). A total of 6174 clinical notes were matched with hospital-specific custom NYHA class diagnosis codes. Machine learning-based methods outperformed a rule-based method. The best machine-learning method was a random forest with n-gram features (F-measure: 93.78%).Conclusions: NYHA class is documented in different parts in EHR for HF patients and the documentation rate is lower than expected. NLP methods are a feasible way to extract NYHA class information from clinical notes.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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