Helicobacter pylori Multidrug Resistance Due to Misuse of Antibiotics in Iran.
Background: Helicobacter pylori might become highly resistant to antibiotics taken through the life time of patients. This study examined the change in antibiotic resistance of H. pylori by time. Methods: Out of 985 dyspeptic patients who were referred to the endoscopy unit of Shariati hospital duri...
| Publicado en: | Archives of Iranian Medicine (AIM) Vol. 21; no. 7; pp. 283 - 289 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Academy of Medical Sciences of I.R. Iran
Jul2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130909006&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130909006 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10292977 5DHN jtl: Archives of Iranian Medicine (AIM) issn: 10292977 maglogo: N pubinfo: dt: Jul2018 vid: 21 iid: 7 pid: 42042 pub: Academy of Medical Sciences of I.R. Iran place: , <Blank> artinfo: ui: 130909006 130909006 130909006 130909006 ppf: 283 ppct: 6 formats: tig: atl: Helicobacter pylori Multidrug Resistance Due to Misuse of Antibiotics in Iran. aug: au: Saniee, Parastoo Hosseini, Farideh Kadkhodaei, Sara Siavoshi, Farideh Khalili-Samani, Saman affil: Department of Microbiology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran sug: subj: Drug Resistance, Microbial Helicobacter Infections Therapy Human Iran Geographic Locations Patient Care Helicobacter Pylori Dyspepsia Referral and Consultation Endoscopy Biopsy Urease Research Subject Recruitment Metronidazole Ofloxacin Ciprofloxacin Tetracycline Male Female Middle Age Gastritis Diagnosis Peptic Ulcer Diagnosis Middle Aged: 45-64 years Male Female ab: Background: Helicobacter pylori might become highly resistant to antibiotics taken through the life time of patients. This study examined the change in antibiotic resistance of H. pylori by time. Methods: Out of 985 dyspeptic patients who were referred to the endoscopy unit of Shariati hospital during 2010-2017, 218 patients with gastric biopsies positive for rapid urease test (RUT) and H. pylori culture were recruited in the study. H. pylori isolates were examined for resistance to 8 currently used antibiotics by the disc diffusion method. Results were compared with those from our three previous studies. The frequency of multidrug resistance (MDR) was also assessed. Results: The highest resistance rate was to metronidazole (MTZ) (79.4%) followed by ofloxacin (OFX) (58.7%), ciprofloxacin (CIP) (46.8%), levofloxacin (LVX) (45%), tetracycline (TET) (38.5%), clarithromycin (CLR) (34.4%), amoxicillin (AMX) (27.1%) and furazolidone (FRZ) (23.9%). No significant difference was found between resistance of H. pylori isolates from male and female <40 and >40 years old and patients with gastritis and peptic ulcer. The highest rates of MDR were to MTZ+OFX (4.6%), MTZ+OFX+TET (2.8%), MTZ+OFX+CIP+LVX (6.4%) and MTZ+OFX+TET+ CIP+LVX (5%). Conclusion: Resistance to MTZ increased from 33%-55.6% in previous studies to 79.4% by time, to CLR increased from 1.4-7.3% to 34.4%, to TET increased from 0-38.1% to 38.5%, to AMX increased from 1.4%-7.3% to 27.1% and to FRZ increased from 0%-4.5% to 23.9%. Resistance to FQs was 45%-58.7%. Increase in H. pylori antibiotic resistance indicates antibiotic misuse. In Iran, with a considerable number of H. pylori- infected patients, antibiotic therapy should be saved for high risk patients and according to local antibiotic resistance patterns. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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