Underlying Systemic Diseases in Pyoderma Gangrenosum: A Systematic Review and Meta-Analysis.
Background: There is little consensus regarding the prevalence and distribution of underlying systemic diseases among patients with pyoderma gangrenosum.Objective: The objective of this study was to synthesize existing data on the prevalence of associated systemic diseases in patients with pyoderma...
| Publicado en: | American Journal of Clinical Dermatology Vol. 19; no. 4; pp. 479 - 488 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130918074&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130918074 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11750561 C4Q jtl: American Journal of Clinical Dermatology issn: 11750561 maglogo: N pubinfo: dt: Aug2018 vid: 19 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130918074 130918074 130918074 10.1007/s40257-018-0356-7 130918074 ppf: 479 ppct: 9 formats: tig: atl: Underlying Systemic Diseases in Pyoderma Gangrenosum: A Systematic Review and Meta-Analysis. aug: au: Kridin, Khalaf Cohen, Arnon D. Amber, Kyle T. affil: Department of Dermatology, Rambam Health Care Campus, PO Box 9602, 31096, Haifa, Israel sug: subj: Pyoderma Gangrenosum Complications Human Systematic Review Meta Analysis Prevalence Medline Embase Confidence Intervals Inflammatory Bowel Diseases Etiology Arthritis Etiology Hematologic Neoplasms Etiology Checklists ab: Background: There is little consensus regarding the prevalence and distribution of underlying systemic diseases among patients with pyoderma gangrenosum.Objective: The objective of this study was to synthesize existing data on the prevalence of associated systemic diseases in patients with pyoderma gangrenosum.Methods: We performed a systematic review and meta-analysis of observational studies in MEDLINE, EMBASE, and Scopus (1823-2017). The quality of evidence was assessed using a modified Newcastle-Ottawa Scale. A meta-analysis was performed using random-effects models to estimate pooled prevalence rates with 95% confidence intervals.Results: Twenty-one eligible studies comprising 2611 patients with pyoderma gangrenosum were included in the quantitative synthesis. The overall random-effects pooled prevalence of associated systemic diseases was 56.8% (95% confidence interval 45.5-67.4). The leading underlying disease was inflammatory bowel disease (17.6%; 95% confidence interval 13.0-22.7), followed by arthritis (12.8%; 95% confidence interval 9.2-16.9), hematological malignancies (8.9%; 95% confidence interval 6.5-11.6), and solid malignancies (7.4%; 95% confidence interval 5.8-9.1). In 16.3% (95% confidence interval 7.7-27.1) of cases, the onset of pyoderma gangrenosum was attributed to the pathergy phenomenon.Conclusions: More than half of patients with pyoderma gangrenosum present with a relevant underlying disease. Inflammatory bowel disease and arthritis are the most frequently associated diseases. Relative to the reported literature, the pooled prevalence of arthritis and hematological malignancies is lower, while the pooled prevalence of solid malignancies is higher. Owing to the high level of heterogeneity among most of the comparisons, results should be interpreted with caution. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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