Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness.
Because the visual cortices are contra-laterally organized, inter-hemispheric transfer tasks have been used to behaviorally probe how information briefly presented to one hemisphere of the visual cortex is integrated with responses resulting from the ipsi- or contra-lateral motor cortex. By forcing...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 4; pp. 942 - 962 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130953528&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130953528 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2018 vid: 12 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130953528 130953528 NLM28808866 10.1007/s11682-017-9750-7 NLM28808866 130953528 ppf: 942 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness. aug: au: Diwadkar, Vaibhav A. Bellani, Marcella Chowdury, Asadur Savazzi, Silvia Perlini, Cinzia Marinelli, Veronica Zoccatelli, Giada Alessandrini, Franco Ciceri, Elisa Rambaldelli, Gianluca Ruggieri, Mirella Carlo Altamura, A. Marzi, Carlo A. Brambilla, Paolo affil: Brain Imaging Research Division, Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Suite 5B, 3901 Chrysler Drive, 48201, Detroit, MI, USA sug: subj: Dominance, Cerebral Physiology Brain Physiology Transfer (Psychology) Hand Physiology Gray Matter Physiology Adult Gray Matter Brain Mapping Male Magnetic Resonance Imaging Female Neuronal Plasticity Physiology Brain Young Adult Clinical Assessment Tools Adult: 19-44 years Male Female ab: Because the visual cortices are contra-laterally organized, inter-hemispheric transfer tasks have been used to behaviorally probe how information briefly presented to one hemisphere of the visual cortex is integrated with responses resulting from the ipsi- or contra-lateral motor cortex. By forcing rapid information exchange across diverse regions, these tasks robustly activate not only gray matter regions, but also white matter tracts. It is likely that the response hand itself (dominant or non-dominant) modulates gray and white matter activations during within and inter-hemispheric transfer. Yet the role of uni-manual responses and/or right hand dominance in modulating brain activations during such basic tasks is unclear. Here we investigated how uni-manual responses with either hand modulated activations during a basic visuo-motor task (the established Poffenberger paradigm) alternating between inter- and within-hemispheric transfer conditions. In a large sample of strongly right-handed adults (n = 49), we used a factorial combination of transfer condition [Inter vs. Within] and response hand [Dominant(Right) vs. Non-Dominant (Left)] to discover fMRI-based activations in gray matter, and in narrowly defined white matter tracts. These tracts were identified using a priori probabilistic white matter atlases. Uni-manual responses with the right hand strongly modulated activations in gray matter, and notably in white matter. Furthermore, when responding with the left hand, activations during inter-hemispheric transfer were strongly predicted by the degree of right-hand dominance, with increased right-handedness predicting decreased fMRI activation. Finally, increasing age within the middle-aged sample was associated with a decrease in activations. These results provide novel evidence of complex relationships between uni-manual responses in right-handed subjects, and activations during within- and inter-hemispheric transfer suggest that the organization of the motor system exerts sophisticated functional effects. Moreover, our evidence of activation in white matter tracts is consistent with prior studies, confirming fMRI-detectable white matter activations which are systematically modulated by experimental condition. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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