Prospective changes in neural alcohol cue reactivity in at-risk adolescents.
Adolescence represents an ideal time for elucidating the etiology of cue reactivity profiles. This study examined the influence of three risk factors consistently associated with heavy adolescent drinking on alcohol cue reactivity. Youth were first assessed while still naïve to alcohol (12-14 years...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 4; pp. 931 - 942 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130953531&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130953531 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2018 vid: 12 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130953531 130953531 NLM28801730 10.1007/s11682-017-9757-0 NLM28801730 130953531 ppf: 931 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prospective changes in neural alcohol cue reactivity in at-risk adolescents. aug: au: Nguyen-Louie, Tam T. Courtney, Kelly E. Squeglia, Lindsay M. Bagot, Kara Eberson, Sonja Migliorini, Robyn Alcaraz, Alexis R. Tapert, Susan F. Pulido, Carmen affil: Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA sug: subj: Brain Visual Perception Physiology Brain Physiopathology Alcohol-Related Disorders Physiopathology Alcohol-Related Disorders Disease Susceptibility Female Brain Mapping Oxygen Blood Cues Prospective Studies Child Magnetic Resonance Imaging Cerebrovascular Circulation Adolescence Male Reproduction Child: 6-12 years Adolescent: 13-18 years Female Male ab: Adolescence represents an ideal time for elucidating the etiology of cue reactivity profiles. This study examined the influence of three risk factors consistently associated with heavy adolescent drinking on alcohol cue reactivity. Youth were first assessed while still naïve to alcohol (12-14 years old) and followed after transitioning into alcohol use (17-21 years old). The effects of family history of substance use disorder, sex, and history of early of dating (i.e., before 14 years of age) on BOLD response contrast to alcohol picture cues were examined in a linear mixed model, controlling for age and alcohol use patterns at follow-up. Activation to alcohol picture cues differed as a function of risk factor and time. At baseline, family history positive youth showed greater activation to alcohol cues than family history negative peers in the right middle occipital and anterior cingulate gyri. Youth with a history of early-dating showed greater activation to alcohol cues, compared to non-early daters, in the left anterior cingulate/white matter region. Girls showed greater activation to alcohol than boys at baseline in left middle frontal gyrus. At follow-up, after drinking started, patterns reversed for each risk factor. These results indicate that even prior to initiating alcohol use, adolescents showed differences in activation to alcohol cues based on their family history, dating history, and sex. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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