Changes in dynamic resting state network connectivity following aphasia therapy.
Resting state magnetic resonance imaging (rsfMRI) permits observation of intrinsic neural networks produced by task-independent correlations in low frequency brain activity. Various resting state networks have been described, with each thought to reflect common engagement in some shared function. Th...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 4; pp. 1141 - 1150 |
|---|---|
| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130953541&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130953541 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2018 vid: 12 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130953541 130953541 NLM29064020 10.1007/s11682-017-9771-2 NLM29064020 130953541 ppf: 1141 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Changes in dynamic resting state network connectivity following aphasia therapy. aug: au: Duncan, E. Susan Small, Steven L. affil: Departments of Cognitive Sciences and Neurology, University of California, Irvine, 92697, Irvine, CA, USA sug: subj: Aphasia Physiopathology Brain Physiopathology Aphasia Rehabilitation Recovery Physiology Aged Aphasia Etiology Neural Pathways Stroke Physiopathology Middle Age Adult Male Neuronal Plasticity Magnetic Resonance Imaging Treatment Outcomes Brain Mapping Stroke Complications Female Narratives Aphasia Stroke Therapy, Computer Assisted Neural Pathways Physiopathology Brain Clinical Assessment Tools Scales Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Resting state magnetic resonance imaging (rsfMRI) permits observation of intrinsic neural networks produced by task-independent correlations in low frequency brain activity. Various resting state networks have been described, with each thought to reflect common engagement in some shared function. There has been limited investigation of the plasticity in these network relationships after stroke or induced by therapy. Twelve individuals with language disorders after stroke (aphasia) were imaged at multiple time points before (baseline) and after an imitation-based aphasia therapy. Language assessment using a narrative production task was performed at the same time points. Group independent component analysis (ICA) was performed on the rsfMRI data to identify resting state networks. A sliding window approach was then applied to assess the dynamic nature of the correlations among these networks. Network correlations during each 30-second window were used to cluster the data into ten states for each window at each time point for each subject. Correlation was performed between changes in time spent in each state and therapeutic gains on the narrative task. The amount of time spent in a single one of the (ten overall) dynamic states was positively associated with behavioral improvement on the narrative task at the 6-week post-therapy maintenance interval, when compared with either baseline or assessment immediately following therapy. This particular state was characterized by minimal correlation among the task-independent resting state networks. Increased functional independence and segregation of resting state networks underlies improvement on a narrative production task following imitation-based aphasia treatment. This has important clinical implications for the targeting of noninvasive brain stimulation in post-stroke remediation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|