Stability of MRI metrics in the advanced research core of the NCAA-DoD concussion assessment, research and education (CARE) consortium.
The NCAA-DoD Concussion Assessment, Research, and Education (CARE) consortium is performing a large-scale, comprehensive study of sport related concussions in college student-athletes and military service academy cadets. The CARE "Advanced Research Core" (ARC), is focused on executing a cutting-edge...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 4; pp. 1121 - 1141 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130953545&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130953545 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2018 vid: 12 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130953545 130953545 NLM29064019 130953545 10.1007/s11682-017-9775-y NLM29064019 130953545 ppf: 1121 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Stability of MRI metrics in the advanced research core of the NCAA-DoD concussion assessment, research and education (CARE) consortium. aug: au: Nencka, Andrew S. Meier, Timothy B. Wang, Yang Muftuler, L. Tugan Wu, Yu-Chien Saykin, Andrew J. Harezlak, Jaroslaw Brooks, M. Alison Giza, Christopher C. Difiori, John Guskiewicz, Kevin M. Mihalik, Jason P. LaConte, Stephen M. Duma, Stefan M. Broglio, Steven McAllister, Thomas McCrea, Michael A. Koch, Kevin M. affil: Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA sug: subj: Magnetic Resonance Imaging Methods Brain Brain Concussion Software Athletic Injuries Physiopathology Students Brain Concussion Etiology Brain Concussion Physiopathology Relaxation Female Male Reproducibility of Results Magnetic Resonance Imaging Equipment and Supplies Image Processing, Computer Assisted Prospective Studies Human Colleges and Universities Brain Physiopathology Military Personnel Athletic Injuries Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Scales Female Male ab: The NCAA-DoD Concussion Assessment, Research, and Education (CARE) consortium is performing a large-scale, comprehensive study of sport related concussions in college student-athletes and military service academy cadets. The CARE "Advanced Research Core" (ARC), is focused on executing a cutting-edge investigative protocol on a subset of the overall CARE athlete population. Here, we present the details of the CARE ARC MRI acquisition and processing protocol along with preliminary analyzes of within-subject, between-site, and between-subject stability across a variety of MRI biomarkers. Two experimental datasets were utilized for this analysis. First, two "human phantom" subjects were imaged multiple times at each of the four CARE ARC imaging sites, which utilize equipment from two imaging vendors. Additionally, a control cohort of healthy athletes participating in non-contact sports were enrolled in the study at each CARE ARC site and imaged at four time points. Multiple morphological image contrasts were acquired in each MRI exam; along with quantitative diffusion, functional, perfusion, and relaxometry imaging metrics. As expected, the imaging markers were found to have varying levels of stability throughout the brain. Importantly, between-subject variance was generally found to be greater than within-subject and between-site variance. These results lend support to the expectation that cross-site and cross-vendor advanced quantitative MRI metrics can be utilized to improve analytic power in assessing sensitive neurological variations; such as those effects hypothesized to occur in sports-related-concussion. This stability analysis provides a crucial foundation for further work utilizing this expansive dataset, which will ultimately be freely available through the Federal Interagency Traumatic Brain Injury Research Informatics System. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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