Risk stratification of oxaliplatin induced peripheral neurotoxicity applying electrophysiological testing of dorsal sural nerve.
Purpose: We aimed to verify the predictiveness of dorsal sural nerve neurophysiological monitoring in obtaining risk stratification for oxaliplatin-induced peripheral neurotoxicity (OXAPN).Methods: We conducted a secondary analysis on a cohort of 110 colorectal cancer patients who were evaluated cli...
| Publicado en: | Supportive Care in Cancer Vol. 26; no. 9; pp. 3143 - 3152 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=130970848&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 130970848 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Sep2018 vid: 26 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 130970848 130970848 NLM29594485 130970848 10.1007/s00520-018-4170-9 NLM29594485 130970848 ppf: 3143 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Risk stratification of oxaliplatin induced peripheral neurotoxicity applying electrophysiological testing of dorsal sural nerve. aug: au: Cavaletti, Guido Alberti, Paola Cazzaniga, Marina E. Cortinovis, Diego Rossi, Emanuela Valsecchi, Maria G. Argyriou, Andreas A. Kalofonos, Haralabos P. Briani, Chiara Campagnolo, Marta Cacciavillani, Mario Bruna, Jordi Velasco, Roser affil: Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, U8 Building, 1st Floor, Room 1.10, Via Cadore, 48, 20900, Monza, MB, Italy sug: subj: Antineoplastic Agents Adverse Effects Colorectal Neoplasms Drug Therapy Peripheral Nervous System Diseases Chemically Induced Neurotoxicity Syndromes Etiology Tibial Nerve Physiopathology Risk Factors Human Adult Female Aged Male Antineoplastic Agents Pharmacodynamics Organoplatinum Compounds Adverse Effects Prospective Studies Middle Age Funding Source Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: We aimed to verify the predictiveness of dorsal sural nerve neurophysiological monitoring in obtaining risk stratification for oxaliplatin-induced peripheral neurotoxicity (OXAPN).Methods: We conducted a secondary analysis on a cohort of 110 colorectal cancer patients who were evaluated clinically and neurophysiologically before chemotherapy, at mid-treatment and at discontinuation. We applied the classification tree analysis method to predict the end-of-treatment OXAPN neurophysiological diagnosis, using data recorded at mid-treatment. We then ascertained the correlation between the obtained classes and neurological impairment at the end of treatment (Fisher's exact test).Results: Dorsal sural nerve monitoring enabled us to stratify oxaliplatin-treated patients into risk classes with an implemented approach to neurophysiology application in this setting. Neurological outcome at discontinuation was predicted by neurophysiological monitoring performed during chemotherapy administration.Conclusions: We demonstrated the role that neurophysiology may play in clinical trials as an early surrogate marker that can predict OXAPN development at the end of treatment. Specifically, we propose abnormal dorsal sural sensory nerve testing as an early biomarker in identifying patients at high risk of eventually developing OXAPN. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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