X chromosome gain is related to increased androgen receptor expression in male breast cancer.
X chromosome gain has been previously described in male breast cancer (MBC). Androgen receptor (AR) gene is located on X chromosome. The aim of this study was to investigate the role of the X chromosome gain in the development of MBC and its relation with AR gene copy number and expression.The X chr...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 473; no. 2; pp. 155 - 164 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131051404&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131051404 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Aug2018 vid: 473 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131051404 131051404 NLM29802469 131051404 10.1007/s00428-018-2377-2 NLM29802469 131051404 ppf: 155 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: X chromosome gain is related to increased androgen receptor expression in male breast cancer. aug: au: Di Oto, Enrico Biserni, Giovanni B. Varga, Zsuzsanna Morandi, Luca Cucchi, Maria C. Masetti, Riccardo Foschini, Maria P. affil: Department of Biomedical and Neuromotor Sciences, University of Bologna, Unit of Anatomic Pathology “M. Malpighi”, Bellaria Hospital, Via Altura, 3, 40139, Bologna, Italy sug: subj: Breast Neoplasms, Male Sex Chromosome Aberrations Genetics Receptors, Cell Surface Carcinoma, Ductal, Breast Middle Age Gene Amplification Carcinoma, Ductal, Breast Metabolism Aged Breast Neoplasms, Male Metabolism Aged, 80 and Over Male Chromosomes Adult Funding Source Human Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Adult: 19-44 years Male ab: X chromosome gain has been previously described in male breast cancer (MBC). Androgen receptor (AR) gene is located on X chromosome. The aim of this study was to investigate the role of the X chromosome gain in the development of MBC and its relation with AR gene copy number and expression.The X chromosome status was assessed in 66 cases of male invasive and in situ duct breast carcinoma, in 34 cases of gynecomastia associated with cancer, and in 11 cases of tumor-free gynecomastia. Cases were tested by fluorescence in situ hybridization (FISH) to assess the X chromosome status and AR amplification. AR expression was studied by immunohistochemistry (IHC). In addition, AR methylation status was assessed.X chromosome gain was observed in 74.7% of invasive duct carcinoma, in 20.6% of in situ duct carcinoma, and in 14.6% of gynecomastia when associated with cancer, while all cases of tumor-free gynecomastia showed wild X chromosome asset. AR gene copy number when increased paralleled the number of X chromosomes. AR IHC expression was observed in 100% of MBC tested. AR gene methylation status revealed low level or absence of methylation.These data suggest that X chromosome can play a role in the neoplastic transformation of male breast epithelium. X chromosome gain is paralleled by AR gene polysomy. Polysomic AR genes show low methylation levels and high AR protein expression on IHC. These data should be taken into consideration for MBC treatment planning. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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