Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma (PMChRCC).
Pigmented microcystic chromophobe renal cell carcinoma (PMChRCC) is a recently described morphologic variant of ChRCC. We have identified 42 cases in 40 patients in the last 24 years. We have investigated their clinical, morphologic, immunohistochemical, and cytogenetic features. Chromosomal abnorma...
| Published in: | Virchows Archiv: European Journal of Pathology Vol. 473; no. 2; pp. 209 - 218 |
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| Main Authors: | , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Aug2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131051405&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131051405 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Aug2018 vid: 473 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131051405 131051405 NLM29931469 131051405 10.1007/s00428-018-2389-y NLM29931469 131051405 ppf: 209 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma (PMChRCC). aug: au: Gutiérrez, Francisco Javier Queipo Panizo, Ángel Tienza, Antonio Rodriguez, Irene Sola, Jesús Javier Temprana-Salvador, Jordi de Torres, Inés Pardo-Mindán, Javier affil: Hospital San Jorge, Avenida Martínez de Velasco no. 36, 22004, Huesca, Spain sug: subj: Carcinoma, Renal Cell In Situ Hybridization Neoplasms, Cystic, Mucinous, and Serous Kidney Neoplasms Immunohistochemistry Female Human Genes Chromosomes Predictive Value of Tests Time Factors Phenotype Aged, 80 and Over Middle Age Neoplasms, Cystic, Mucinous, and Serous Therapy Carcinoma, Renal Cell Therapy Male Disease Susceptibility Adult Neoplasms, Cystic, Mucinous, and Serous Mortality Kidney Neoplasms Therapy Diagnosis, Differential Aged Carcinoma, Renal Cell Mortality Spain Kidney Neoplasms Mortality Treatment Outcomes Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Pigmented microcystic chromophobe renal cell carcinoma (PMChRCC) is a recently described morphologic variant of ChRCC. We have identified 42 cases in 40 patients in the last 24 years. We have investigated their clinical, morphologic, immunohistochemical, and cytogenetic features. Chromosomal abnormalities of chromosomes 7 and 17 were evaluated by automated dual-color silver-enhanced in situ hybridization on paraffin-embedded tissue. Chromosomal imbalance was defined on the basis of changes in both chromosomal index and signal distribution. The main age was 60.20 years, being 34 males and 6 women. The mean tumor diameter was 4.84 cm, with 39 intrarenal tumors. Grossly, the tumors were solid with a brown dark colored. Microscopically, tumors consisted of pale and eosinophilic cells arranged in microcysts or microalveolar in a cribriform pattern; there were microcalcifications and a dark brown pigment, mostly extracellular. One case showed sarcomatoid transformation. All tumors were positive for epithelial membrane antigen (EMA), Claudin 7, and E-cadherin. Monosomy of 7 and 17 chromosomes was present in 1/36 cases and 2/37 cases, respectively. Polysomy of chromosome 7 and 17 was found in 26/36 cases and in 4/37, respectively. With a median follow-up of 74.05 months, 37 patients were alive without disease and two were alive with disease progression. PMChRCCs expand the morphologic spectrum of the ChRCC with an unusual immunohistochemical profile. Cytogenetically, they showed monosomy to chromosome (CHR) 17 as other ChRCCs and polysomy of CHR 7 infrequent to ChRCCs. We present the probably largest series of PMCRCC, confirming their low aggressive behavior, with exceptional sarcomatoid transformation and distant metastases. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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