Assessment of Neurocognitive Functions in 7-Year-Old Children at Familial High Risk for Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7.
Importance: Children at familial high risk of schizophrenia spectrum disorders (FHR-SZ) or bipolar disorder (FHR-BP) exhibit neurocognitive impairments. Large studies of neurocognition in young children at familial high risk at the same age are important to differentiate the pathophysiology and deve...
| Published in: | JAMA Psychiatry Vol. 75; no. 8; pp. 844 - 853 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
American Medical Association
Aug2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131062025&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131062025 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2168622X FT4X jtl: JAMA Psychiatry issn: 2168622X maglogo: N pubinfo: dt: Aug2018 vid: 75 iid: 8 pid: 30 pub: American Medical Association place: Chicago, Illinois artinfo: ui: 131062025 131062025 NLM29926086 131062025 10.1001/jamapsychiatry.2018.1415 NLM29926086 131062025 ppf: 844 ppct: 9 formats: tig: atl: Assessment of Neurocognitive Functions in 7-Year-Old Children at Familial High Risk for Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7. aug: au: Hemager, Nicoline Plessen, Kerstin J. Thorup, Anne Christiani, Camilla Ellersgaard, Ditte Spang, Katrine Søborg Burton, Birgitte Klee Gregersen, Maja Søndergaard, Anne Greve, Aja Neergaard Gantriis, Ditte Lou Poulsen, Gry Seidman, Larry J. Mors, Ole Nordentoft, Merete Jepsen, Jens Richardt Møllegaard Spang, Katrine Søborg Søndergaard, Anne Jepsen, Jens Richardt Møllegaard affil: Mental Health Centre Copenhagen, Mental Health Services, Capital Region of Denmark, Copenhagen sug: subj: Schizophrenia Psychology Bipolar Disorder Epidemiology Competence (Legal) Psychosocial Factors Bipolar Disorder Schizophrenia Diagnosis Bipolar Disorder Psychosocial Factors Bipolar Disorder Diagnosis Schizophrenia Epidemiology Human Early Diagnosis Phenotype Neuropsychological Tests Female Data Collection Patient History Taking Statistics and Numerical Data Early Intervention Methods Denmark Male Executive Function Child Validation Studies Comparative Studies Evaluation Research Multicenter Studies Child: 6-12 years Female Male ab: Importance: Children at familial high risk of schizophrenia spectrum disorders (FHR-SZ) or bipolar disorder (FHR-BP) exhibit neurocognitive impairments. Large studies of neurocognition in young children at familial high risk at the same age are important to differentiate the pathophysiology and developmental trajectory of these 2 groups.Objective: To characterize neurocognitive functions in 7-year-old children with FHR-SZ or FHR-BP and a control population.Design, Setting, and Participants: This multisite population-based cohort study collected data from January 1, 2013, to January 31, 2016, in the first wave of the Danish High Risk and Resilience Study VIA 7 at 2 university hospital research sites in Copenhagen and Aarhus using Danish registries. Participants (n = 514) included 197 children with FHR-SZ, 118 with FHR-BP, and 199 controls matched with the FHR-SZ group for age, sex, and municipality. Assessors were blinded to risk status.Exposures: Parents with schizophrenia, bipolar disorder, or neither diagnosis.Main Outcomes and Measures: Neurocognitive functions were measured across 23 tests. Four neurocognitive domains were derived by principal component analysis, including processing speed and working memory, verbal functions, executive and visuospatial functions, and declarative memory and attention.Results: A total of 514 children aged 7 years were included in the analysis (46.3% girls), consisting of 197 children with FHR-SZ (46.2% girls), 118 with FHR-BP (46.6% girls), and 199 controls (46.2% girls). Children with FHR-SZ were significantly impaired compared with controls on processing speed and working memory (Cohen d = 0.50; P < .001), executive and visuospatial functions (Cohen d = 0.28; P = .03), and declarative memory and attention (Cohen d = 0.29; P = .02). Compared with children with FHR-BP, children with FHR-SZ performed significantly poorer in processing speed and working memory (Cohen d = 0.40; P = .002), executive and visuospatial functions (Cohen d = 0.35; P = .008), and declarative memory and attention (Cohen d = 0.31; P = .03). Children with FHR-BP and controls did not differ.Conclusions and Relevance: Children with FHR-SZ had widespread neurocognitive impairments, supporting the hypothesis of neurocognitive functions as endophenotypes of schizophrenia. The absence of neurocognitive deficits in children with FHR-BP suggests distinct neurodevelopmental manifestations in these familial high-risk groups at this age. Early detection of children with FHR-SZ and cognitive impairments is warranted to investigate associations of neurocognition with transition to psychosis, add to the knowledge of their developmental pathophysiology, and inform early intervention programs. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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