A Bayesian Analysis of Prenatal Maternal Factors Predicting Nonadherence to Infant HIV Medication in South Africa.
While efforts to prevent mother-to-child transmission of HIV been successful in some districts in South Africa, rates remain unacceptably high in others. This study utilized Bayesian logistic regression to examine maternal-level predictors of adherence to infant nevirapine prophylaxis, including int...
| Publicado en: | AIDS & Behavior Vol. 22; no. 9; pp. 2947 - 2956 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131072907&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131072907 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10907165 G1T jtl: AIDS & Behavior issn: 10907165 maglogo: N pubinfo: dt: Sep2018 vid: 22 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131072907 131072907 131072907 10.1007/s10461-017-2010-4 131072907 ppf: 2947 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Bayesian Analysis of Prenatal Maternal Factors Predicting Nonadherence to Infant HIV Medication in South Africa. aug: au: Cook, R. R. Peltzer, K. Weiss, S. M. Rodriguez, V. J. Jones, D. L. affil: Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1400 NW 10th Ave. Suite 404A, 33136, Miami, FL, USA sug: subj: Probability Prenatal Care Maternal Behavior Medication Compliance HIV Infections Diagnosis Nevirapine Therapeutic Use Intimate Partner Violence AIDS Serodiagnosis Truth Disclosure Depression South Africa Postnatal Period Anti-Retroviral Agents Odds Ratio Disease Transmission, Vertical Prevention and Control Child Human Logistic Regression Child: 6-12 years ab: While efforts to prevent mother-to-child transmission of HIV been successful in some districts in South Africa, rates remain unacceptably high in others. This study utilized Bayesian logistic regression to examine maternal-level predictors of adherence to infant nevirapine prophylaxis, including intimate partner violence, maternal adherence, HIV serostatus disclosure reaction, recency of HIV diagnosis, and depression. Women (N = 303) were assessed during pregnancy and 6 weeks postpartum. Maternal adherence to antiretroviral therapy during pregnancy predicted an 80% reduction in the odds of infant nonadherence [OR 0.20, 95% posterior credible interval (.11,.38)], and maternal prenatal depression predicted an increase [OR 1.04, 95% PCI (1.01, 1.08)]. Results suggest that in rural South Africa, failure to provide medication to infants may arise from shared risk factors with maternal nonadherence. Intervening to increase maternal adherence and reduce depression may improve adherence to infant prophylaxis and ultimately reduce vertical transmission rates. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|