Putting it all together: established and emerging MRI techniques for detecting and measuring liver fibrosis.
Chronic injury to the liver leads to inflammation and hepatocyte necrosis, which when untreated can lead to myofibroblast activation and fibrogenesis with deposition of fibrous tissue. Over time, liver fibrosis can accumulate and lead to cirrhosis and end-stage liver disease with associated portal h...
| Publicado en: | Pediatric Radiology Vol. 48; no. 9; pp. 1256 - 1273 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images review tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131094509&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131094509 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Aug2018 vid: 48 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131094509 131094509 NLM30078038 131094509 10.1007/s00247-018-4083-2 NLM30078038 131094509 ppf: 1256 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Putting it all together: established and emerging MRI techniques for detecting and measuring liver fibrosis. aug: au: Serai, Suraj D. Trout, Andrew T. Miethke, Alexander Diaz, Eric Xanthakos, Stavra A. Dillman, Jonathan R. affil: Department of Radiology, MLC 5031, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., 45229, Cincinnati, OH, USA sug: subj: Ultrasonography Methods Liver Cirrhosis Magnetic Resonance Imaging Methods Diagnosis, Differential Child Child: 6-12 years ab: Chronic injury to the liver leads to inflammation and hepatocyte necrosis, which when untreated can lead to myofibroblast activation and fibrogenesis with deposition of fibrous tissue. Over time, liver fibrosis can accumulate and lead to cirrhosis and end-stage liver disease with associated portal hypertension and liver failure. Detection and accurate measurement of the severity of liver fibrosis are important for assessing disease severity and progression, directing patient management, and establishing prognosis. Liver biopsy, generally considered the clinical standard of reference for detecting and measuring liver fibrosis, is invasive and has limitations, including sampling error, relatively high cost, and possible complications. For these reasons, liver biopsy is suboptimal for fibrosis screening, longitudinal monitoring, and assessing therapeutic efficacy. A variety of established and emerging qualitative and quantitative noninvasive MRI methods for detecting and staging liver fibrosis might ultimately serve these purposes. In this article, we review multiple MRI methods for detecting and measuring liver fibrosis and discuss the diagnostic performance and specific strengths and limitations of the various techniques. pubtype: Academic Journal doctype: diagnostic images review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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