Resuscitative endovascular balloon occlusion of the aorta: what is the optimum occlusion time in an ovine model of hemorrhagic shock?
Purpose: The aim of this study is to evaluate the early survival and organ damage following 30 and 60 min of thoracic resuscitative endovascular balloon occlusion of the aorta (REBOA) in an ovine model of severe hemorrhagic shock.Methods: Eighteen sheep were induced into shock by undergoing a 35 % c...
| Publicado en: | European Journal of Trauma & Emergency Surgery Vol. 44; no. 4; pp. 511 - 519 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131114607&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131114607 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18639933 3C05 jtl: European Journal of Trauma & Emergency Surgery issn: 18639933 maglogo: N pubinfo: dt: Aug2018 vid: 44 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131114607 131114607 131114607 10.1007/s00068-016-0732-z 131114607 ppf: 511 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Resuscitative endovascular balloon occlusion of the aorta: what is the optimum occlusion time in an ovine model of hemorrhagic shock? aug: au: Reva, V. A. Matsumura, Y. Hörer, T. Sveklov, D. A. Denisov, A. V. Telickiy, S. Y. Seleznev, A. B. Bozhedomova, E. R. Matsumoto, J. Samokhvalov, I. M. Morrison, J. J. affil: Department of War Surgery, Kirov Military Medical Academy, 6, Lebedeva Str., 194044, Saint-Petersburg, Russian Federation sug: subj: Aorta Physiopathology Shock, Hemorrhagic Therapy Catheterization Methods Balloon Occlusion Animal Studies Sheep Time Factors Survival ab: Purpose: The aim of this study is to evaluate the early survival and organ damage following 30 and 60 min of thoracic resuscitative endovascular balloon occlusion of the aorta (REBOA) in an ovine model of severe hemorrhagic shock.Methods: Eighteen sheep were induced into shock by undergoing a 35 % controlled exsanguination over 30 min. Animals were randomized into three groups: 60-min REBOA 30 min after the bleeding (60-REBOA), 30-min REBOA 60 min after the bleeding (30-REBOA) and no-REBOA control (n-REBOA). Resuscitation with crystalloids and whole blood was initiated 20 and 80 min after the induction of shock. Animals were observed for 24 h with serial potassium and lactate measurements. Autopsy was performed to evaluate organ damage.Results: Two animals of the n-REBOA group died within 90 min of shock induction; no hemorrhagic deaths were observed in the REBOA groups. Twenty-four-hour survival for the 60-, 30-, and n-REBOA groups was 0/6, 5/6, and 4/6 (P = 0.002). In 60-REBOA, potassium and lactate were increased at 270-min time point: from 4.3 to 5.1 mEq/l and from 3.7 to 5.1 mmol/L, respectively. Both these values were significantly higher than in the n-REBOA group (P = 0.029 for potassium and P = 0.039 for lactate). Autopsy revealed acute tubular necrosis in all died REBOA group animals.Conclusions: In this ovine model of severe hemorrhagic shock, REBOA can be used to prevent early death from hemorrhage; however, 60 min of occlusion results in significant metabolic derangement and organ damage that offsets this gain. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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