Impact of deformable image registration on dose accumulation applied electrocardiograph-gated 4DCT in the heart and left ventricular myocardium during esophageal cancer radiotherapy.
Background: The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the heart and left ventricular myocardium (LVM) by applying DIR.Methods: The electroc...
| Publicado en: | Radiation Oncology Vol. 13; no. 1 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
8/10/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131175756&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131175756 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1748717X 38NX jtl: Radiation Oncology issn: 1748717X maglogo: N pubinfo: dt: 8/10/2018 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 131175756 131175756 NLM30097045 10.1186/s13014-018-1093-z NLM30097045 131175756 ppct: 1 formats: tig: atl: Impact of deformable image registration on dose accumulation applied electrocardiograph-gated 4DCT in the heart and left ventricular myocardium during esophageal cancer radiotherapy. aug: au: Tong, Ying Yin, Yong Cheng, Pinjing Gong, Guanzhong affil: Radiation Physics Department of Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China sug: subj: Esophageal Neoplasms Radiotherapy Electrocardiography Methods Esophageal Neoplasms Heart Radiation Effects Tomography, X-Ray Computed Algorithms Heart Ventricle Radiation Effects Myocardium Image Processing, Computer Assisted Heart Aged Radiotherapy, Computer-Assisted Retrospective Design Female Male Heart Ventricle Middle Age Radiation Dosage Pilot Studies Adult Impact of Events Scale Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background: The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the heart and left ventricular myocardium (LVM) by applying DIR.Methods: The electrocardiograph-gated four-dimensional CT (ECG-gated 4DCT) data of 21 patients were analyzed retrospectively. The heart and LVM were contoured on 20 phases of 4DCT (0%, 5%,…,95%). The heart and LVM in the minimum volume/dice similarity coefficient (DSC) phase (Volume min/DSC min) were deformed to the maximum volume/DSC phase (Volume max/ DSC max), which used the intensity-based free-form DIR algorithm of MIM software. The dose was deformed according to the deformation vector. The variations in volume, mean dose (Dmean), V20, V30 and V40 for the heart and LVM before and after DIR were compared, and the reference phase was the Volume max/DSC max phase.Results: For the heart, the difference between the pre- and post-registration Volume min and Volume max were reduced from 13.87 to 1.72%; the DSC was increased from 0.899 to 0.950 between the pre- and post-registration DSC min phase relative to the DSC max phase. The post-registration Dmean, V20, V30 and V40 of the heart were statistically significant compared to those in the Volume max/DSC max phase (p < 0.05). For the LVM, the difference between the pre- and post-registration Volume min and Volume max were only reduced from 18.77 to 17.38%; the DSC reached only 0.733 in the post-registration DSC min phase relative to the DSC max phase. The pre- and post-registration volume, Dmean, V20, V30 and V40 of the LVM were all statistically significant compared to those in the Volume max/DSC max phase (p < 0.05).Conclusions: There was no significant relationship between the variation in dose-volume parameters and the variation in the volume and morphology for the heart; however, the inconsistency of the variation in the volume and morphology for the LVM was a major factor that led to uncertainty in the dose-volume evaluation. In addition, the individualized local deformation registration technology should be applied in dose accumulation for the heart and LVM. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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