Prevalence and determinants of left ventricular diastolic dysfunction in obese subjects and the role of left ventricular global longitudinal strain and mass normalized to height.
Background: Left ventricular (LV) diastolic dysfunction (DD) is a frequent finding in obesity and may predispose to the development of heart failure (HF). However, no data are available on the prevalence of DD after the introduction of the 2016 Recommendations of the American Society of Echocardiogr...
| Publicado en: | Echocardiography Vol. 35; no. 8; pp. 1124 - 1132 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131209490&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131209490 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Aug2018 vid: 35 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 131209490 131209490 131209490 10.1111/echo.13890 131209490 ppf: 1124 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Prevalence and determinants of left ventricular diastolic dysfunction in obese subjects and the role of left ventricular global longitudinal strain and mass normalized to height. aug: au: Dini, Frank Lloyd Fabiani, Iacopo Miccoli, Mario Galeotti, Gian Giacomo Pugliese, Nicola Riccardo D'Agostino, Andreina Scartabelli, Alessandra Conte, Lorenzo Salvetti, Guido Santini, Ferruccio Pedrinelli, Roberto affil: Cardiovascular and Thoracic Department, University of Pisa, Pisa, Italy sug: subj: Ventricular Dysfunction, Left Obesity Echocardiography Methods Ventricular Ejection Fraction Prevalence Body Height Human Male Female Prospective Studies Descriptive Statistics Adult Middle Age Aged Echocardiography, Doppler Multivariate Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Left ventricular (LV) diastolic dysfunction (DD) is a frequent finding in obesity and may predispose to the development of heart failure (HF). However, no data are available on the prevalence of DD after the introduction of the 2016 Recommendations of the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Methods and results: To assess the impact of the new Recommendations on the prevalence of DD and on their clinical and echocardiographic correlates in obesity, a prospective study was performed in 588 subjects with an ejection fraction (EF) ≥50% and no history of HF either obese (n = 402; mean age: 47 ± 12 years; women 71%; body mass index [BMI]: 44 ± 8 kg/m2), overweight (n = 86; BMI: 28 ± 1 kg/m2), or with a normal weight (n = 100; BMI: 22 ± 2 kg/m2). All subjects underwent an echocardiographic and Doppler study, including the assessment of global longitudinal strain (GLS). DD occurred in 19% of obese patients, 12% of overweight subjects, and 2% of normal weight subjects. We used multivariable logistic analysis to assess the risk of DD. In patients with BMI ≥30 kg/m2, LV mass normalized to height (2.7) (OR: 1.04, P = .0028), and GLS (OR: 0.85, P = .0032) were associated with an increased risk of DD followed by EF (OR: 0.91, P = .045), diabetes (OR: 1.91, P = .065), and systolic blood pressure (OR: 1.02, P = .076). Conclusion: These results show that DD is highly prevalent among obese subjects and impairment of longitudinal systolic mechanics, as reflected by GLS reduction, and LV mass normalized to height are major independent predictors of DD in this patients' population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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