Comparison of platelets production and destruction in ITP patients with or without H.pylori infection...Iranian Congress of Gastroenterology and Hepatology – ICGH 2017. November 23-24, 2017.
Introduction: Immune thrombocytopenic purpura (ITP) is a common hematological disease and its pathophysiology is not fully understood. The purpose of this study was to determine the production and destruction rate of platelets in ITP patients with and without H.pylori infection. Therefore we tried t...
| Publicado en: | Iranian Journal of Gastroenterology & Hepatology (GOVARESH) Vol. 22; no. 3; p. 21 |
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| Autores principales: | , , , , , |
| Formato: | abstract proceedings research Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
2017 Supplement
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Introduction: Immune thrombocytopenic purpura (ITP) is a common hematological disease and its pathophysiology is not fully understood. The purpose of this study was to determine the production and destruction rate of platelets in ITP patients with and without H.pylori infection. Therefore we tried to comparison the reticulated platelets (RP) as young platelets and glycocalicin (GC) as destruction marker in H.pylori positive and negative ITP patients. Methods: A total of 47 newly diagnosed primary ITP patients (platelets < 100×109/L) and 47 non-thrombocytopenic controls were included in the study. H.pylori infection was evaluated by urease breath test and serological tests. Platelets were isolated from plasma samples of patients and controls then RP rates were analyzed by flow cytometry assay. In addition, GC value was determined by enzyme-linked immunosorbent assay (ELISA). In finally, we compaired RP% and GC index in HP+ ITP and HP- ITP together. Results: Our study has shown that reticulated platelets from H.pylori positive ITP patients were found to be significantly higher than H.pyori negative group also similar relation were obtain about GC index. Conclusion: Platelet production and destruction rate is much higher in patients with ITP in H.pylori positive group than H.pylori negative. |
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