Impact of white matter hyperintensities on surrounding white matter tracts.
Purpose: It is unclear how white matter hyperintensities disrupt surrounding white matter tracts. The aim of this tractography study was to determine the spatial relationship between diffusion characteristics along white matter tracts and the distance from white matter hyperintensities.Methods: Diff...
| Publicado en: | Neuroradiology Vol. 60; no. 9; pp. 933 - 945 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131259928&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131259928 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Sep2018 vid: 60 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131259928 131259928 131259928 10.1007/s00234-018-2053-x 131259928 ppf: 933 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Impact of white matter hyperintensities on surrounding white matter tracts. aug: au: Reginold, William Sam, Kevin Poublanc, Julien Fisher, Joe Crawley, Adrian Mikulis, David J. affil: Department of Medical Imaging, University of Toronto, 263 McCaul Street, M5T 1W7, Toronto, ON, Canada sug: subj: White Matter Pathology Brain Diseases Diagnosis Magnetic Resonance Imaging Methods Human Nerve Degeneration ab: Purpose: It is unclear how white matter hyperintensities disrupt surrounding white matter tracts. The aim of this tractography study was to determine the spatial relationship between diffusion characteristics along white matter tracts and the distance from white matter hyperintensities.Methods: Diffusion tensor 3-T MRI scans were acquired in 29 participants with white matter hyperintensities. In each subject, tractography by the fiber assignment by continuous tracking method was used to segment corticospinal tracts. Mean diffusivity, radial diffusivity, axial diffusivity, and fractional anisotropy were measured along corticospinal tracts in relation to white matter hyperintensities. Diffusion characteristics along tracts were correlated with distance from white matter hyperintensities and were also compared between tracts traversing and not traversing white matter hyperintensities.Results: In tracts not traversing through white matter hyperintensities, increasing distance from white matter hyperintensities was associated with decreased mean diffusivity (p = 0.002) and increased fractional anisotropy (p = 0.006). In tracts traversing white matter hyperintensities, compared to tracts not traversing white matter hyperintensites, the mean diffusivity was higher at 6-8 voxels, axial diffusivity higher at 4-8 voxels, and radial diffusivity higher at 7 voxels away from white matter hyperintensities (all p < 0.006).Conclusion: White matter hyperintensities are associated with two patterns of altered diffusion characteristics in the surrounding white matter tract network. Diffusion characteristics along white matter tracts improve further away from white matter hyperintensities suggestive of a local penumbra pattern. Also, altered diffusion extends further along tracts traversing white matter hyperintensities suggestive of a Wallerian-type degenerative pattern. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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