Measuring liver T2* and cardiac T2* in a single acquisition.
Purpose: The purpose of this study is determine if both liver T2* and cardiac T2* can be measured on a single breath-hold acquisition.Materials and methods: For this IRB-approved retrospective study, 137 patients with dedicated Cardiac MRI and Liver MRI examinations obtained sequentially on 1.5T sca...
| Publicado en: | Abdominal Radiology Vol. 43; no. 9; pp. 2303 - 2309 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131351278&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131351278 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Sep2018 vid: 43 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 131351278 10.1007/s00261-018-1477-4 131351278 ppf: 2303 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Measuring liver T2* and cardiac T2* in a single acquisition. aug: au: Serai, Suraj D. Trout, Andrew T. Fleck, Robert J. Quinn, Charles T. Dillman, Jonathan R. affil: Department of Radiology, MLC 5031, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA sug: ab: Purpose: The purpose of this study is determine if both liver T2* and cardiac T2* can be measured on a single breath-hold acquisition.Materials and methods: For this IRB-approved retrospective study, 137 patients with dedicated Cardiac MRI and Liver MRI examinations obtained sequentially on 1.5T scanners and on the same day were included for analysis. Both the cardiac and liver MRI examinations utilized GRE sequences for quantification of tissue iron. Specifically, T2* was measured using an 8-echo, multi-echo gradient echo single breath-hold sequence. Liver T2* was measured in a blinded manner on images from each of the cardiac and dedicated liver MRI examinations and were correlated. Bland-Altman difference plot was used to assess mean bias.Results: 137 examinations from 93 subjects met inclusion criteria. 10 examination pairs were excluded because the first echo time (TE) on the cardiac MRI was insufficiently short for the very high liver iron content. After exclusion, 127 studies from 89 subjects (67.4% males) were included in the final analysis. The mean subject age (± standard deviation) was 11.5 ± 7.5 years (range 0-29.3 years; median 10.5 years). Mean liver T2* measured on cardiac MRI was 8.3 ± 7.7 ms and mean liver T2* measured on dedicated liver MRI was 7.8 ± 7.4 ms (p < 0.001). There was strong positive correlation between the two liver T2* measurements (r = 0.989, p < 0.0001; 95% CI 0.985-0.992). With the exception of borderline outliers, all values fell within two standard deviations on the Bland-Altman difference plots, with a mean bias of 0.5 ms (range − 1.8 to + 2.7 ms).Conclusion: In most patients with suspected or known iron overload, a single breath-hold GRE sequence may be sufficient to evaluate the iron concentration (T2*) of both the myocardium and the liver. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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