Effect of Heat-Killed Lactobacillus paracasei KW3110 Ingestion on Ocular Disorders Caused by Visual Display Terminal (VDT) Loads: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study.
Background: Visual display terminals (VDTs) emitting blue light can cause ocular disorders including eye fatigue. Some dietary constituents have been reported to be effective in improving ocular disorders while few clinical studies have been performed. We evaluated the effects of heat-killed <italic...
| Publicado en: | Nutrients Vol. 10; no. 8; pp. 1058 - 1059 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
Aug2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=131434685&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 131434685 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Aug2018 vid: 10 iid: 8 pid: 97109 pub: MDPI artinfo: ui: 131434685 131434685 131434685 10.3390/nu10081058 131434685 ppf: 1058 ppct: 1 formats: tig: atl: Effect of Heat-Killed Lactobacillus paracasei KW3110 Ingestion on Ocular Disorders Caused by Visual Display Terminal (VDT) Loads: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study. aug: au: Morita, Yuji Jounai, Kenta Miyake, Mika Inaba, Masaharu Kanauchi, Osamu affil: Research Laboratories for Health Science & Food Technologies, Kirin Company, Ltd., 1-13-5 Fukuura Kanazawa-ku, Yokohama-shi, Kanagawa 236-0004, Japan sug: subj: Lactobacillus Probiotics Pharmacodynamics Eye Drug Effects Computer Terminals Eye Diseases Etiology Fatigue Diet Therapy Human Randomized Controlled Trials Double-Blind Studies In Vitro Studies Retinal Detachment Etiology Light Adverse Effects Japanese Persons Adult Middle Age Dietary Supplements Retinal Detachment Diet Therapy Adult: 19-44 years Middle Aged: 45-64 years ab: Background: Visual display terminals (VDTs) emitting blue light can cause ocular disorders including eye fatigue. Some dietary constituents have been reported to be effective in improving ocular disorders while few clinical studies have been performed. We evaluated the effects of heat-killed <italic>Lactobacillus paracasei</italic> KW 3110 on improving ocular disorders and symptoms of eye fatigue among healthy human subjects with VDT loads. Methods: In vitro, the effect of <italic>L. paracasei</italic> KW3110 on blue light-induced human retinal pigment epithelial (ARPE-19) cell damage. For clinical studies, 62 healthy Japanese volunteers of 35 to 45 years of age who had experienced eye fatigue were randomized into two groups and given a placebo or <italic>L. paracasei</italic> KW3110-containing supplements for eight weeks. The primary endpoint was changes in VDT load-induced eye fatigue as determined by critical flicker frequency four and eight weeks after the start of supplementation. Results: In vitro, blue light-induced human retinal cell death was suppressed with the culture supernatants of cells treated with <italic>L. paracasei</italic> KW3110. In clinical study, the VDT load-induced reduction of critical flicker frequency tended to be milder in the <italic>L. paracasei</italic> KW3110 group when compared with the placebo group during the fourth week. Subgroup analysis classified by the degree of eye fatigue showed that the VDT load-induced reduction of critical flicker frequency was significantly better in the high-level eye fatigue subjects from the <italic>L. paracasei</italic> KW3110 group when compared with the placebo group during the fourth week (<italic>p</italic> = 0.020). Conclusions: <italic>L. paracasei</italic> KW3110 suppressed blue light-induced retinal pigment epithelial cell death. In the clinical study, ingestion of <italic>L. paracasei</italic> KW3110 had a potential to improve eye fatigue induced by VDT loads especially high levels of eye fatigue. However, further studies should be required to show more dependable clinical efficacy of <italic>L. paracasei</italic> KW3110. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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